AICAR Peptide

For Research Use Only. Not for human use.

PubMed (NIH/NLM) records related to this compound for laboratory literature review. Inclusion does not imply suitability for any use beyond controlled research. Each note below is a research-framed summary using compliance-safe wording.

Showing 357 PubMed records. Displaying 10 per page.

1. Fu Y et al. (2025). Liposome-encapsulated AICAR hydrogel regulates macrophage metabolic reprogramming via… [PMID: 40616103]

   Laboratory literature summary: Liposome-encapsulated AICAR hydrogel regulates macrophage metabolic reprogramming via SIK1 activation to alleviate osteoarthritis. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

2. Chandrasekaran K et al. (2024). Laboratory research record on AICAR [PMID: 39795939]

   PubMed laboratory record discussing AICAR in a research context. Review the full methods and limitations on PubMed; research use only.

3. Višnjić D et al. (2021). AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A… [PMID: 34064363]

   Laboratory literature summary: AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

4. Fassett EK et al. (2025). AICAr Inhibition of cardiomyocyte autophagy promotes p62-dependent NRF2 expression and… [PMID: 41231272]

   Laboratory literature summary: AICAr Inhibition of cardiomyocyte autophagy promotes p62-dependent NRF2 expression and protection against doxorubicin toxicity. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

5. Choksey A et al. (2024). AICAR confers prophylactic cardioprotection in doxorubicin-induced heart failure in rats [PMID: 38643934]

   Laboratory literature summary: AICAR confers prophylactic cardioprotection in doxorubicin-induced heart failure in rats. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

6. Gan L et al. (2026). AICAR attenuates ischemia-reperfusion-induced AKI by modulating AMPK-TXNIP-NLRP3… [PMID: 41644729]

   Laboratory literature summary: AICAR attenuates ischemia-reperfusion-induced AKI by modulating AMPK-TXNIP-NLRP3 pathway and energy metabolism. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

7. Aftab F et al. (2023). An intrinsic purine metabolite AICAR blocks lung oncology research models growth by… [PMID: 36810913]

   Laboratory literature summary: An intrinsic purine metabolite AICAR blocks lung oncology research models growth by targeting oncoprotein mucin 1. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

8. Wu Y et al. (2022). AICAR attenuates postoperative abdominal adhesion formation by inhibiting oxidative… [PMID: 36048820]

   Laboratory literature summary: AICAR attenuates postoperative abdominal adhesion formation by inhibiting oxidative stress and promoting mesothelial cell repair. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

9. Chung EJ et al. (2017). AICAR suppresses TNF-α-induced complement factor B in RPE cells [PMID: 29247196]

   Laboratory literature summary: AICAR suppresses TNF-α-induced complement factor B in RPE cells. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

10. Guerrieri D et al. (2015). Exercise-mimetic AICAR transiently benefits brain function [PMID: 26286955]

    Laboratory literature summary: Exercise-mimetic AICAR transiently benefits brain function. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

11. Torres RJ et al. (2018). Aicar effect in early neuronal development [PMID: 29634397]

    Laboratory literature summary: Aicar effect in early neuronal development. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

12. Sobolevsky T et al. (2022). AICAr to SAICAr ratio can serve as additional marker of AICAr use [PMID: 36342242]

    Laboratory literature summary: AICAr to SAICAr ratio can serve as additional marker of AICAr use. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

13. Fan J et al. (2024). Quantification of AICAR and study of metabolic markers after administration [PMID: 38873554]

    Laboratory literature summary: Quantification of AICAR and study of metabolic markers after administration. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

14. Guo F et al. (2016). AICAR induces AMPK-independent programmed necrosis in prostate oncology research… [PMID: 27103440]

    Laboratory literature summary: AICAR induces AMPK-independent programmed necrosis in prostate oncology research models cells. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

15. Krishnan U A et al. (2023). AMPK activation by AICAR reduces diet induced fatty liver in C57BL/6 mice [PMID: 36913846]

    Laboratory literature summary: AMPK activation by AICAR reduces diet induced fatty liver in C57BL/6 mice. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

16. Bush ND et al. (2018). AICAR Prevents Acute Olanzapine-Induced Disturbances in Glucose Homeostasis [PMID: 29581153]

    Laboratory literature summary: AICAR Prevents Acute Olanzapine-Induced Disturbances in Glucose Homeostasis. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

17. Hinkle JS et al. (2022). AICAR stimulates mitochondrial biogenesis and BCAA catabolic enzyme expression in… [PMID: 34798200]

    Laboratory literature summary: AICAR stimulates mitochondrial biogenesis and BCAA catabolic enzyme expression in C2C12 myotubes. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

18. Ahmad I et al. (2021). AICAR decreases acute lung injury by phosphorylating AMPK and upregulating heme… [PMID: 34049949]

    Laboratory literature summary: AICAR decreases acute lung injury by phosphorylating AMPK and upregulating heme oxygenase-1. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

19. Ceschin J et al. (2014). Identification of yeast and research subjects… [PMID: 24778186]

    Laboratory literature summary: Identification of yeast and research subjects 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAr) transporters. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

20. Tsogbadrakh B et al. (2019). AICAR, an AMPK activator, protects against cisplatin-induced acute kidney injury… [PMID: 30616891]

    Laboratory literature summary: AICAR, an AMPK activator, protects against cisplatin-induced acute kidney injury through the JAK/STAT/SOCS pathway. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

21. Lonare S et al. (2024). Characterization of AICAR transformylase/IMP cyclohydrolase (ATIC) bifunctional enzyme… [PMID: 38615986]

    Laboratory literature summary: Characterization of AICAR transformylase/IMP cyclohydrolase (ATIC) bifunctional enzyme from Candidatus Liberibacer asiaticus. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

22. Dennis MR et al. (2025). Cardiovascular and renal effects of 5-aminoimidazole-4-carboxyribonucleoside (AICAR)… [PMID: 40947048]

    Laboratory literature summary: Cardiovascular and renal effects of 5-aminoimidazole-4-carboxyribonucleoside (AICAR) in the deoxycorticosterone acetate (DOCA)-salt rat…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

23. Philippe C et al. (2018). AICAR Antiproliferative Properties Involve the AMPK-Independent Activation of the… [PMID: 29730476]

    Laboratory literature summary: AICAR Antiproliferative Properties Involve the AMPK-Independent Activation of the oncology research models Suppressors LATS 1 and 2. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

24. Börgeson E et al. (2017). AICAR ameliorates high-fat diet-associated pathophysiology in mouse and ex vivo… [PMID: 28188334]

    Laboratory literature summary: AICAR ameliorates high-fat diet-associated pathophysiology in mouse and ex vivo models, independent of adiponectin. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

25. Du L et al. (2019). AICAr suppresses cell proliferation by inducing NTP and dNTP pool imbalances in acute… [PMID: 30702927]

    Laboratory literature summary: AICAr suppresses cell proliferation by inducing NTP and dNTP pool imbalances in acute lymphoblastic leukemia cells. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

26. Dedert CJ et al. (2023). Prior investigation with AICAR Causes the Selective Phosphorylation of mTOR Substrates… [PMID: 37886951]

    Laboratory literature summary: Prior investigation with AICAR Causes the Selective Phosphorylation of mTOR Substrates in C2C12 Cells. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

27. Morishita M et al. (2017). AICAR induces mitochondrial apoptosis in research subjects oncology research models… [PMID: 27878239]

    Laboratory literature summary: AICAR induces mitochondrial apoptosis in research subjects oncology research models cells through an AMPK-dependent pathway. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

28. Lihn AS et al. (2004). AICAR stimulates adiponectin and inhibits cytokines in adipose tissue [PMID: 15033479]

    Laboratory literature summary: AICAR stimulates adiponectin and inhibits cytokines in adipose tissue. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

29. Dembitz V et al. (2019). The ribonucleoside AICAr induces differentiation of myeloid leukemia by activating the… [PMID: 31431503]

    Laboratory literature summary: The ribonucleoside AICAr induces differentiation of myeloid leukemia by activating the ATR/Chk1 via pyrimidine depletion. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

30. Liu J et al. (2021). AICAR suppresses cell proliferation and synergizes with decitabine in myelodysplastic… [PMID: 33788127]

    Laboratory literature summary: AICAR suppresses cell proliferation and synergizes with decitabine in myelodysplastic syndrome via DNA damage induction. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

31. Dolinar K et al. (2018). Nucleosides block AICAR-stimulated activation of AMPK in skeletal muscle and oncology… [PMID: 30230919]

    Laboratory literature summary: Nucleosides block AICAR-stimulated activation of AMPK in skeletal muscle and oncology research models cells. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

32. Idrovo JP et al. (2015). AICAR attenuates organ injury and inflammatory response after intestinal ischemia and… [PMID: 25611433]

    Laboratory literature summary: AICAR attenuates organ injury and inflammatory response after intestinal ischemia and reperfusion. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

33. Kirchner J et al. (2018). AICAR inhibits NFκB DNA binding independently of AMPK to attenuate LPS-triggered… [PMID: 29773845]

    Laboratory literature summary: AICAR inhibits NFκB DNA binding independently of AMPK to attenuate LPS-triggered inflammatory responses in research subjects macrophages. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

34. Verma P et al. (2017). Characterization of AICAR transformylase/IMP cyclohydrolase (ATIC) from Staphylococcus… [PMID: 29063699]

    Laboratory literature summary: Characterization of AICAR transformylase/IMP cyclohydrolase (ATIC) from Staphylococcus lugdunensis. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

35. Wu Y et al. (2016). AMPK activator AICAR promotes 5-FU-induced apoptosis in gastric oncology research… [PMID: 26497305]

    Laboratory literature summary: AMPK activator AICAR promotes 5-FU-induced apoptosis in gastric oncology research models cells. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

36. Zineldeen DH et al. (2023). AICAR Ameliorates Non-Alcoholic Fatty Liver Disease via Modulation of the… [PMID: 36834782]

    Laboratory literature summary: AICAR Ameliorates Non-Alcoholic Fatty Liver Disease via Modulation of the HGF/NF-κB/SNARK Signaling Pathway and Restores Mitochondrial…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

37. Sid B et al. (2014). AICAR induces Nrf2 activation by an AMPK-independent mechanism in hepatocarcinoma cells [PMID: 25058527]

    Laboratory literature summary: AICAR induces Nrf2 activation by an AMPK-independent mechanism in hepatocarcinoma cells. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

38. Khorraminejad-Shirazi M et al. (2020). AICAR and nicotinamide investigation synergistically augment the proliferation and… [PMID: 32014016]

    Laboratory literature summary: AICAR and nicotinamide investigation synergistically augment the proliferation and attenuate senescence-associated changes in…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

39. Kim JE et al. (2008). AMPK activator, AICAR, inhibits palmitate-induced apoptosis in osteoblast [PMID: 18502715]

    Laboratory literature summary: AMPK activator, AICAR, inhibits palmitate-induced apoptosis in osteoblast. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

40. Viglino C et al. (2019). Chronic AICAR investigation prevents metabolic changes in cardiomyocytes exposed to… [PMID: 31152240]

    Laboratory literature summary: Chronic AICAR investigation prevents metabolic changes in cardiomyocytes exposed to free fatty acids. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

41. Nie J et al. (2017). AICAR activates ER stress-dependent apoptosis in gallbladder oncology research models… [PMID: 27847321]

    Laboratory literature summary: AICAR activates ER stress-dependent apoptosis in gallbladder oncology research models cells. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

42. Han L et al. (2023). Ubiquitin Degradation of the AICAR Transformylase/IMP Cyclohydrolase Ade16 Regulates… [PMID: 37504688]

    Laboratory literature summary: Ubiquitin Degradation of the AICAR Transformylase/IMP Cyclohydrolase Ade16 Regulates the behavioral Reproduction of Cryptococcus neoformans. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

43. Tukhovskaya EA et al. (2022). Laboratory research record on AICAR [PMID: 36555360]

    PubMed laboratory record discussing AICAR in a research context. Review the full methods and limitations on PubMed; research use only.

44. Liu S et al. (2015). AICAR-Induced Activation of AMPK Inhibits TSH/SREBP-2/HMGCR Pathway in Liver [PMID: 25933205]

    Laboratory literature summary: AICAR-Induced Activation of AMPK Inhibits TSH/SREBP-2/HMGCR Pathway in Liver. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

45. Spangenburg EE et al. (2013). AICAR inhibits oxygen consumption by intact skeletal muscle cells in culture [PMID: 23813470]

    Laboratory literature summary: AICAR inhibits oxygen consumption by intact skeletal muscle cells in culture. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

46. Jiang L et al. (2019). AICAR prolongs corneal allograft survival via the AMPK-mTOR signaling pathway in mice [PMID: 30856534]

    Laboratory literature summary: AICAR prolongs corneal allograft survival via the AMPK-mTOR signaling pathway in mice. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

47. Dolinar K et al. (2025). Diverse Inhibitors of De Novo Purine Synthesis Promote AICAR-Induced AMPK Activation… [PMID: 40793247]

    Laboratory literature summary: Diverse Inhibitors of De Novo Purine Synthesis Promote AICAR-Induced AMPK Activation and Glucose Uptake in L6 Myotubes. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

48. Wizrah MSI et al. (2022). AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine… [PMID: 36063996]

    Laboratory literature summary: AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

49. Moopanar TR et al. (2006). AICAR inhibits the Na+/H+ exchanger in rat hearts–possible contribution to… [PMID: 16983558]

    Laboratory literature summary: AICAR inhibits the Na+/H+ exchanger in rat hearts–possible contribution to cardioprotection. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

50. Dai YL et al. (2015). AICAR and Metformin Exert AMPK-dependent Effects on INS-1E Pancreatic β-cell Apoptosis… [PMID: 26435693]

    Laboratory literature summary: AICAR and Metformin Exert AMPK-dependent Effects on INS-1E Pancreatic β-cell Apoptosis via Differential Downstream Mechanisms. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

51. Misquitta NS et al. (2023). Combinatorial investigation with exercise and AICAR potentiates the rescue of myotonic… [PMID: 36048859]

    Laboratory literature summary: Combinatorial investigation with exercise and AICAR potentiates the rescue of myotonic dystrophy type 1 mouse muscles in a sex-specific…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

52. Liu Q et al. (2023). Regulation of LRRK2 mRNA stability by ATIC and its substrate AICAR through… [PMID: 37366237]

    Laboratory literature summary: Regulation of LRRK2 mRNA stability by ATIC and its substrate AICAR through ARE-mediated mRNA decay in neurodegeneration research…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

53. Kim YK et al. (2021). AICAR upregulates ABCA1/ABCG1 expression in the retinal pigment epithelium and reduces… [PMID: 34808137]

    Laboratory literature summary: AICAR upregulates ABCA1/ABCG1 expression in the retinal pigment epithelium and reduces Bruch's membrane lipid deposit in ApoE deficient mice. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

54. Banek CT et al. (2013). AICAR administration ameliorates hypertension and angiogenic imbalance in a model of… [PMID: 23417865]

    Laboratory literature summary: AICAR administration ameliorates hypertension and angiogenic imbalance in a model of preeclampsia in the rat. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

55. Boß M et al. (2016). AMPK-independent inhibition of research subjects macrophage ER stress response by AICAR [PMID: 27562249]

    Laboratory literature summary: AMPK-independent inhibition of research subjects macrophage ER stress response by AICAR. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

56. Ceschin J et al. (2015). Disruption of Nucleotide Homeostasis by the Antiproliferative Drug… [PMID: 26283791]

    Laboratory literature summary: Disruption of Nucleotide Homeostasis by the Antiproliferative Drug 5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside Monophosphate (AICAR). Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

57. Zhu H et al. (2018). AICAR-Induced AMPK Activation Inhibits the Noncanonical NF-κB Pathway to Attenuate… [PMID: 30662889]

    Laboratory literature summary: AICAR-Induced AMPK Activation Inhibits the Noncanonical NF-κB Pathway to Attenuate Liver Injury and Fibrosis in BDL Rats. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

58. Tripathi V et al. (2022). Anti-oncology research models Effects of… [PMID: 35135451]

    Laboratory literature summary: Anti-oncology research models Effects of 5-Aminoimidazole-4-Carboxamide-1-β-D-Ribofuranoside (AICAR) on Triple-negative Breast oncology…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

59. Quan H et al. (2015). AICAR Enhances the Phagocytic Ability of Macrophages towards Apoptotic Cells through… [PMID: 26020972]

    Laboratory literature summary: AICAR Enhances the Phagocytic Ability of Macrophages towards Apoptotic Cells through P38 Mitogen Activated Protein Kinase Activation…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

60. Wolan DW et al. (2002). Structural insights into the avian AICAR transformylase mechanism [PMID: 12501179]

    Laboratory literature summary: Structural insights into the avian AICAR transformylase mechanism. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

61. Calder MD et al. (2017). Investigation with AICAR inhibits blastocyst development, trophectoderm… [PMID: 28962017]

    Laboratory literature summary: investigation with AICAR inhibits blastocyst development, trophectoderm differentiation and tight junction formation and function in mice. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

62. Hashempour S et al. (2020). Binding Studies of AICAR and research subjects Serum Albumin by Spectroscopic,… [PMID: 33228044]

    Laboratory literature summary: Binding Studies of AICAR and research subjects Serum Albumin by Spectroscopic, Theoretical, and Computational Methodologies. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

63. Yan S et al. (2021). AICAR enhances the cytotoxicity of PFKFB3 inhibitor in an AMPK signaling-independent… [PMID: 34761330]

    Laboratory literature summary: AICAR enhances the cytotoxicity of PFKFB3 inhibitor in an AMPK signaling-independent manner in colorectal oncology research models cells. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

64. Wang H et al. (2022). Prior AICAR induces elevated glucose uptake concomitant with greater γ3-AMPK… [PMID: 36381195]

    Laboratory literature summary: Prior AICAR induces elevated glucose uptake concomitant with greater γ3-AMPK activation and reduced membrane cholesterol in skeletal…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

65. Böttcher K et al. (2021). AICAR and compound C negatively modulate HCC-induced primary research subjects hepatic… [PMID: 33406006]

    Laboratory literature summary: AICAR and compound C negatively modulate HCC-induced primary research subjects hepatic stellate cell activation in vitro. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

66. Nagahara K et al. (2016). AICAR Attenuates TNFα-Induced Inappropriate Secretion of Monocyte Chemoattractant… [PMID: 27170207]

    Laboratory literature summary: AICAR Attenuates TNFα-Induced Inappropriate Secretion of Monocyte Chemoattractant Protein-1 and Adiponectin in 3T3-L1 Adipocytes. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

67. Huang Y et al. (2017). AICAR Administration Attenuates Hemorrhagic Hyperglycemia and Lowers Oxygen Debt in… [PMID: 28955248]

    Laboratory literature summary: AICAR Administration Attenuates Hemorrhagic Hyperglycemia and Lowers Oxygen Debt in Anesthetized research models Rabbits. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

68. Martin LM et al. (2019). 5-Amino-1-β-D-Ribofuranosyl-Imidazole-4-Carboxamide (AICAR) Reduces Peripheral… [PMID: 31269729]

    Laboratory literature summary: 5-Amino-1-β-D-Ribofuranosyl-Imidazole-4-Carboxamide (AICAR) Reduces Peripheral Inflammation by Macrophage Phenotype Shift. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

69. Nakamaru K et al. (2005). AICAR, an activator of AMP-activated protein kinase, down-regulates the insulin… [PMID: 15694368]

    Laboratory literature summary: AICAR, an activator of AMP-activated protein kinase, down-regulates the insulin receptor expression in HepG2 cells. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

70. Pyla R et al. (2022). AICAR promotes endothelium-independent vasorelaxation by activating AMP-activated… [PMID: 35503763]

    Laboratory literature summary: AICAR promotes endothelium-independent vasorelaxation by activating AMP-activated protein kinase via increased ZMP and decreased ATP/ADP…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

71. Wang L et al. (2015). Wnt/β-Catenin Mediates AICAR Effect to Increase GATA3 Expression and Inhibit Adipogenesis [PMID: 26109067]

    Laboratory literature summary: Wnt/β-Catenin Mediates AICAR Effect to Increase GATA3 Expression and Inhibit Adipogenesis. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

72. Erickson KA et al. (2012). AICAR inhibits ceramide biosynthesis in skeletal muscle [PMID: 23134616]

    Laboratory literature summary: AICAR inhibits ceramide biosynthesis in skeletal muscle. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

73. Polet M et al. (2026). Rapid Analysis of Urinary AICAR by Liquid Chromatography-Isotope Ratio Mass Spectrometry [PMID: 41955491]

    Laboratory literature summary: Rapid Analysis of Urinary AICAR by Liquid Chromatography-Isotope Ratio Mass Spectrometry. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

74. Alba G et al. (2020). AICAR Stimulates the Pluripotency Transcriptional Complex in Embryonic Stem Cells… [PMID: 32832780]

    Laboratory literature summary: AICAR Stimulates the Pluripotency Transcriptional Complex in Embryonic Stem Cells Mediated by PI3K, GSK3β, and β-Catenin. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

75. Sobolevsky T et al. (2019). Urinary concentrations of AICAR and mannitol in athlete population [PMID: 30548818]

    Laboratory literature summary: Urinary concentrations of AICAR and mannitol in athlete population. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

76. Guo XH et al. (2020). AICAR-induced activation of AMPK inhibits the migration of TSCC cells by targeting ZO-1 [PMID: 31604003]

    Laboratory literature summary: AICAR-induced activation of AMPK inhibits the migration of TSCC cells by targeting ZO-1. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

77. Liu J et al. (2016). AICAR enhances insulin signaling via downregulation of miR-29 [PMID: 26359920]

    Laboratory literature summary: AICAR enhances insulin signaling via downregulation of miR-29. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

78. Rae C et al. (2019). AMPK activation by AICAR sensitizes prostate oncology research models cells to… [PMID: 30774777]

    Laboratory literature summary: AMPK activation by AICAR sensitizes prostate oncology research models cells to radiotherapy. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

79. Sun Y et al. (2007). AICAR induces phosphorylation of AMPK in an ATM-dependent, LKB1-independent manner [PMID: 17786544]

    Laboratory literature summary: AICAR induces phosphorylation of AMPK in an ATM-dependent, LKB1-independent manner. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

80. Namgaladze D et al. (2013). AICAR inhibits PPARγ during monocyte differentiation to attenuate inflammatory… [PMID: 23531513]

    Laboratory literature summary: AICAR inhibits PPARγ during monocyte differentiation to attenuate inflammatory responses to atherogenic lipids. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

81. Rao E et al. (2016). AMPK-dependent and independent effects of AICAR and compound C on T-cell responses [PMID: 27177226]

    Laboratory literature summary: AMPK-dependent and independent effects of AICAR and compound C on T-cell responses. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

82. de Laat MA et al. (2015). AICAR administration affects glucose metabolism by upregulating the novel glucose… [PMID: 26116041]

    Laboratory literature summary: AICAR administration affects glucose metabolism by upregulating the novel glucose transporter, GLUT8, in equine skeletal muscle. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

83. Wu W et al. (2011). AICAR, a small chemical molecule, primes osteogenic differentiation of adult… [PMID: 22198598]

    Laboratory literature summary: AICAR, a small chemical molecule, primes osteogenic differentiation of adult mesenchymal stem cells. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

84. Fu LY et al. (2024). Central administration of AICAR attenuates hypertension via AMPK/Nrf2 pathway in the… [PMID: 38341079]

    Laboratory literature summary: Central administration of AICAR attenuates hypertension via AMPK/Nrf2 pathway in the hypothalamic paraventricular nucleus of…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

85. Salt IP et al. (2000). 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) inhibits insulin-stimulated… [PMID: 11016448]

    Laboratory literature summary: 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

86. Hall DT et al. (2018). The AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), but not… [PMID: 29844217]

    Laboratory literature summary: The AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation-associated cachectic…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

87. Page T et al. (1994). Investigation of Lesch-Nyhan syndrome with AICAR [PMID: 7660927]

    Laboratory literature summary: investigation of Lesch-Nyhan syndrome with AICAR. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

88. Scudiero O et al. (2016). New synthetic AICAR derivatives with enhanced AMPK and ACC activation [PMID: 26446934]

    Laboratory literature summary: New synthetic AICAR derivatives with enhanced AMPK and ACC activation. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

89. Aschenbach WG et al. (2002). Effect of AICAR investigation on glycogen metabolism in skeletal muscle [PMID: 11872652]

    Laboratory literature summary: Effect of AICAR investigation on glycogen metabolism in skeletal muscle. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

90. Zhu XY et al. (2020). AICAR and Decitabine Enhance the Sensitivity of K562 Cells to Imatinib by Promoting… [PMID: 33123902]

    Laboratory literature summary: AICAR and Decitabine Enhance the Sensitivity of K562 Cells to Imatinib by Promoting Mitochondrial Activity. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

91. Su CC et al. (2019). AICAR Induces Apoptosis and Inhibits Migration and Invasion in Prostate oncology… [PMID: 30987073]

    Laboratory literature summary: AICAR Induces Apoptosis and Inhibits Migration and Invasion in Prostate oncology research models Cells Through an AMPK/mTOR-Dependent…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

92. Piper T et al. (2014). Determination of ¹³C/¹² C ratios of endogenous urinary 5-amino-imidazole-4-carboxamide… [PMID: 24760559]

    Laboratory literature summary: Determination of ¹³C/¹² C ratios of endogenous urinary 5-amino-imidazole-4-carboxamide 1β-D-ribofuranoside (AICAR). Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

93. McCrimmon RJ et al. (2002). Laboratory research record on AICAR [PMID: 12376337]

    PubMed laboratory record discussing AICAR in a research context. Review the full methods and limitations on PubMed; research use only.

94. Alshuweishi Y et al. (2025). AICAR Inhibits Insulin-Stimulated Glucose Uptake in 3T3-L1 Adipocytes via an… [PMID: 41294864]

    Laboratory literature summary: AICAR Inhibits Insulin-Stimulated Glucose Uptake in 3T3-L1 Adipocytes via an AMPK-Independent, ZMP-Dependent Mechanism. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

95. Douillet DC et al. (2019). Metabolomics and proteomics identify the toxic form and the associated cellular… [PMID: 30478173]

    Laboratory literature summary: Metabolomics and proteomics identify the toxic form and the associated cellular binding targets of the anti-proliferative drug AICAR. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

96. Chen KH et al. (2014). The AMPK agonist AICAR inhibits TGF-β1 induced activation of kidney myofibroblasts [PMID: 25188319]

    Laboratory literature summary: The AMPK agonist AICAR inhibits TGF-β1 induced activation of kidney myofibroblasts. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

97. ElAzzouny MA et al. (2015). Metabolomics Analysis Reveals that AICAR Affects Glycerolipid, Ceramide and Nucleotide… [PMID: 26107620]

    Laboratory literature summary: Metabolomics Analysis Reveals that AICAR Affects Glycerolipid, Ceramide and Nucleotide Synthesis Pathways in INS-1 Cells. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

98. Lanner JT et al. (2012). AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK… [PMID: 22231556]

    Laboratory literature summary: AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

99. Lane SL et al. (2020). Laboratory research record on AICAR [PMID: 32592403]

    PubMed laboratory record discussing AICAR in a research context. Review the full methods and limitations on PubMed; research use only.

100. Cieslik KA et al. (2017). Aicar investigation reduces interstitial fibrosis in aging mice: Suppression of the… [PMID: 28826664]

     Laboratory literature summary: Aicar investigation reduces interstitial fibrosis in aging mice: Suppression of the inflammatory fibroblast. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

101. Buisson C et al. (2017). Implementation of AICAR analysis by GC-C-IRMS for anti-doping purposes [PMID: 29032594]

     Laboratory literature summary: Implementation of AICAR analysis by GC-C-IRMS for anti-doping purposes. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

102. González-Gironès DM et al. (2013). AICAR induces Bax/Bak-dependent apoptosis through upregulation of the BH3-only… [PMID: 23605481]

     Laboratory literature summary: AICAR induces Bax/Bak-dependent apoptosis through upregulation of the BH3-only proteins Bim and Noxa in mouse embryonic fibroblasts. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

103. Lee H et al. (2011). AICAR, an activator of AMPK, inhibits adipogenesis via the WNT/β-catenin pathway in… [PMID: 21491080]

     Laboratory literature summary: AICAR, an activator of AMPK, inhibits adipogenesis via the WNT/β-catenin pathway in 3T3-L1 adipocytes. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

104. Gu Y et al. (2025). Nanoparticle-based methionine and AICAR delivery elicits a robust antitumor immune… [PMID: 40570967]

     Laboratory literature summary: Nanoparticle-based methionine and AICAR delivery elicits a robust antitumor immune response. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

105. Egawa T et al. (2014). AICAR-induced activation of AMPK negatively regulates myotube hypertrophy through the… [PMID: 24347059]

     Laboratory literature summary: AICAR-induced activation of AMPK negatively regulates myotube hypertrophy through the HSP72-mediated pathway in C2C12 skeletal muscle cells. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

106. Wong JKY et al. (2017). Doping control study of AICAR in post-race urine and plasma samples from horses [PMID: 28407446]

     Laboratory literature summary: Doping control study of AICAR in post-race urine and plasma samples from horses. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

107. Jhun BS et al. (2005). AICAR suppresses IL-2 expression through inhibition of GSK-3 phosphorylation and NF-AT… [PMID: 15910743]

     Laboratory literature summary: AICAR suppresses IL-2 expression through inhibition of GSK-3 phosphorylation and NF-AT activation in Jurkat T cells. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

108. Riedinger C et al. (2018). High-glucose toxicity is mediated by AICAR-transformylase/IMP cyclohydrolase and… [PMID: 29414769]

     Laboratory literature summary: High-glucose toxicity is mediated by AICAR-transformylase/IMP cyclohydrolase and mitigated by AMP-activated protein kinase in…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

109. Khamaru P et al. (2022). AMPK activator AICAR in combination with anti-mouse IL10 mAb restores the… [PMID: 36375313]

     Laboratory literature summary: AMPK activator AICAR in combination with anti-mouse IL10 mAb restores the functionality of intra-tumoral Tfh cells in the 4T1 mouse model. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

110. Tomita K et al. (2005). AICAR, an AMPK activator, has protective effects on alcohol-induced fatty liver in rats [PMID: 16385230]

     Laboratory literature summary: AICAR, an AMPK activator, has protective effects on alcohol-induced fatty liver in rats. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

111. Hu L et al. (2019). AMPK agonist AICAR ameliorates portal hypertension and liver cirrhosis via NO pathway… [PMID: 30721324]

     Laboratory literature summary: AMPK agonist AICAR ameliorates portal hypertension and liver cirrhosis via NO pathway in the BDL rat model. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

112. Kong L et al. (2021). AICAR, an AMP-Activated Protein Kinase Activator, Ameliorates Acute… [PMID: 34531748]

     Laboratory literature summary: AICAR, an AMP-Activated Protein Kinase Activator, Ameliorates Acute Pancreatitis-Associated Liver Injury Partially Through Nrf2-Mediated…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

113. Blanco CL et al. (2018). Effects of intravenous AICAR (5-aminoimidazole-4-carboximide riboside) administration… [PMID: 30540820]

     Laboratory literature summary: Effects of intravenous AICAR (5-aminoimidazole-4-carboximide riboside) administration on insulin signaling and resistance in premature…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

114. Mukhopadhyay S et al. (2015). 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR) enhances the observed… [PMID: 26323019]

     Laboratory literature summary: 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR) enhances the observed endpoints of rapamycin in research subjects oncology…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

115. Kobilo T et al. (2014). AMPK agonist AICAR improves cognition and motor coordination in young and aged mice [PMID: 24443745]

     Laboratory literature summary: AMPK agonist AICAR improves cognition and motor coordination in young and aged mice. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

116. Thomas A et al. (2010). Quantification of urinary AICAR concentrations as a matter of doping controls [PMID: 20225061]

     Laboratory literature summary: Quantification of urinary AICAR concentrations as a matter of doping controls. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

117. Zheng D et al. (2008). AMPK activation with AICAR provokes an acute fall in plasma [K+] [PMID: 18003746]

     Laboratory literature summary: AMPK activation with AICAR provokes an acute fall in plasma [K+]. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

118. Suwa M et al. (2015). A comparison of chronic AICAR investigation-induced metabolic adaptations in red and… [PMID: 25388945]

     Laboratory literature summary: A comparison of chronic AICAR investigation-induced metabolic adaptations in red and white muscles of rats. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

119. Mendler M et al. (2018). Laboratory research record on AICAR [PMID: 29546577]

     PubMed laboratory record discussing AICAR in a research context. Review the full methods and limitations on PubMed; research use only.

120. Miyake M et al. (2012). AMPK activation by AICAR inhibits myogenic differentiation and myostatin expression in… [PMID: 22622802]

     Laboratory literature summary: AMPK activation by AICAR inhibits myogenic differentiation and myostatin expression in cattle. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

121. Kjøbsted R et al. (2019). TBC1D4 Is Necessary for Enhancing Muscle Insulin Sensitivity in Response to AICAR and… [PMID: 31175100]

     Laboratory literature summary: TBC1D4 Is Necessary for Enhancing Muscle Insulin Sensitivity in Response to AICAR and Contraction. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

122. Santidrián AF et al. (2010). AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the… [PMID: 20664053]

     Laboratory literature summary: AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

123. Jeppesen J et al. (2009). Contractions but not AICAR increase FABPpm content in rat muscle sarcolemma [PMID: 19142713]

     Laboratory literature summary: Contractions but not AICAR increase FABPpm content in rat muscle sarcolemma. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

124. Moon HY et al. (2019). Conditioned media from AICAR-studied skeletal muscle cells increases neuronal… [PMID: 30391731]

     Laboratory literature summary: Conditioned media from AICAR-studied skeletal muscle cells increases neuronal differentiation of adult neural progenitor cells. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

125. Rodríguez-Calvo R et al. (2015). AICAR Protects against High Palmitate/High Insulin-Induced Intramyocellular Lipid… [PMID: 26649034]

     Laboratory literature summary: AICAR Protects against High Palmitate/High Insulin-Induced Intramyocellular Lipid Accumulation and Insulin Resistance in HL-1 Cardiac…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

126. Lempiäinen J et al. (2012). AMPK activator AICAR ameliorates ischaemia reperfusion injury in the rat kidney [PMID: 22324445]

     Laboratory literature summary: AMPK activator AICAR ameliorates ischaemia reperfusion injury in the rat kidney. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

127. Sajan MP et al. (2010). AICAR and metformin, but not exercise, increase muscle glucose transport through… [PMID: 19887597]

     Laboratory literature summary: AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

128. Matsiukevich D et al. (2017). The AMPK Activator Aicar Ameliorates Age-Dependent Myocardial Injury in Murine… [PMID: 27513082]

     Laboratory literature summary: The AMPK Activator Aicar Ameliorates Age-Dependent Myocardial Injury in Murine Hemorrhagic Shock. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

129. Samsonov MV et al. (2021). AICAR Protects Vascular Endothelial Cells from Oxidative Injury Induced by the… [PMID: 35008640]

     Laboratory literature summary: AICAR Protects Vascular Endothelial Cells from Oxidative Injury Induced by the Long-Term Palmitate Excess. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

130. Gaskin FS et al. (2009). AICAR preconditioning prevents postischemic leukocyte rolling and adhesion: role of… [PMID: 19152177]

     Laboratory literature summary: AICAR preconditioning prevents postischemic leukocyte rolling and adhesion: role of K(ATP) channels and heme oxygenase. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

131. Pold R et al. (2005). Laboratory research record on AICAR [PMID: 15793229]

     PubMed laboratory record discussing AICAR in a research context. Review the full methods and limitations on PubMed; research use only.

132. Tsai WL et al. (2020). Whether AICAR in developmental research context or Lactation Prevents Hypertension… [PMID: 32053935]

     Laboratory literature summary: Whether AICAR in developmental research context or Lactation Prevents Hypertension Programmed by High Saturated Fat Diet: A Pilot Study. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

133. Hürlimann HC et al. (2011). Physiological and toxic effects of purine intermediate 5-amino-4-imidazolecarboxamide… [PMID: 21757731]

     Laboratory literature summary: Physiological and toxic effects of purine intermediate 5-amino-4-imidazolecarboxamide ribonucleotide (AICAR) in yeast. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

134. Awwad O et al. (2018). The AMPK-activator AICAR in thyroid oncology research models: effects on CXCL8… [PMID: 29546654]

     Laboratory literature summary: The AMPK-activator AICAR in thyroid oncology research models: effects on CXCL8 secretion and on CXCL8-induced neoplastic cell migration. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

135. Wang H et al. (2024). Independent and combined effects of calorie restriction and AICAR on glucose uptake… [PMID: 38181403]

     Laboratory literature summary: Independent and combined effects of calorie restriction and AICAR on glucose uptake and insulin signaling in skeletal muscles from…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

136. Jose C et al. (2011). AICAR inhibits oncology research models cell growth and triggers cell-type distinct… [PMID: 21692240]

     Laboratory literature summary: AICAR inhibits oncology research models cell growth and triggers cell-type distinct effects on OXPHOS biogenesis, oxidative stress and…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

137. Buhl ES et al. (2002). Long-term AICAR administration reduces metabolic disturbances and lowers blood… [PMID: 12086950]

     Laboratory literature summary: Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

138. Shah AK et al. (2011). AICAR induced AMPK activation potentiates neuronal insulin signaling and glucose uptake [PMID: 21414288]

     Laboratory literature summary: AICAR induced AMPK activation potentiates neuronal insulin signaling and glucose uptake. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

139. Kjøbsted R et al. (2015). Prior AICAR stimulation increases insulin sensitivity in mouse skeletal muscle in an… [PMID: 25552597]

     Laboratory literature summary: Prior AICAR stimulation increases insulin sensitivity in mouse skeletal muscle in an AMPK-dependent manner. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

140. Shi X et al. (2013). AICAR sustains J1 mouse embryonic stem cell self-renewal and pluripotency by… [PMID: 23988673]

     Laboratory literature summary: AICAR sustains J1 mouse embryonic stem cell self-renewal and pluripotency by regulating transcription factor and epigenetic modulator…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

141. Sakoda H et al. (2002). Activation of AMPK is essential for AICAR-induced glucose uptake by skeletal muscle… [PMID: 12006353]

     Laboratory literature summary: Activation of AMPK is essential for AICAR-induced glucose uptake by skeletal muscle but not adipocytes. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

142. Leick L et al. (2010). PGC-1{alpha} is required for AICAR-induced expression of GLUT4 and mitochondrial… [PMID: 20628026]

     Laboratory literature summary: PGC-1{alpha} is required for AICAR-induced expression of GLUT4 and mitochondrial proteins in mouse skeletal muscle. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

143. Drake JC et al. (2010). AICAR investigation for 14 days normalizes metabolic research models-induced… [PMID: 20844264]

     Laboratory literature summary: AICAR investigation for 14 days normalizes metabolic research models-induced dysregulation of TORC1 signaling and translational capacity…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

144. Zang Y et al. (2008). AICAR induces astroglial differentiation of neural stem cells via activating the… [PMID: 18077446]

     Laboratory literature summary: AICAR induces astroglial differentiation of neural stem cells via activating the JAK/STAT3 pathway independently of AMP-activated…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

145. Wang Y et al. (2024). Two-Dimensional Liquid Chromatography Purified GC/C/IRMS Doping Control Method:… [PMID: 39232419]

     Laboratory literature summary: Two-Dimensional Liquid Chromatography Purified GC/C/IRMS Doping Control Method: Analysis of Endogenous and Exogenous Sources in Urine…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

146. Theodoropoulou S et al. (2010). Retinoblastoma cells are inhibited by aminoimidazole carboxamide ribonucleotide… [PMID: 20371623]

     Laboratory literature summary: Retinoblastoma cells are inhibited by aminoimidazole carboxamide ribonucleotide (AICAR) partially through activation of AMP-dependent kinase. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

147. Gonzalez-Franquesa A et al. (2021). Insulin and 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Differentially… [PMID: 34449730]

     Laboratory literature summary: Insulin and 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Differentially Regulate the Skeletal Muscle Cell Secretome. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

148. Gaidhu MP et al. (2009). Prolonged AICAR-induced AMP-kinase activation promotes energy dissipation in white… [PMID: 19050316]

     Laboratory literature summary: Prolonged AICAR-induced AMP-kinase activation promotes energy dissipation in white adipocytes: novel mechanisms integrating HSL and ATGL. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

149. Yang Z et al. (2012). The full capacity of AICAR to reduce metabolic research models-induced inflammation… [PMID: 23183898]

     Laboratory literature summary: The full capacity of AICAR to reduce metabolic research models-induced inflammation and insulin resistance requires myeloid SIRT1. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

150. Pokrywka A et al. (2014). Metabolic modulators of the exercise response: doping control analysis of an agonist… [PMID: 25179079]

     Laboratory literature summary: Metabolic modulators of the exercise response: doping control analysis of an agonist of the peroxisome proliferator-activated receptor δ…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

151. Spurr IB et al. (2012). Targeting oncology research models proliferation with a small-molecule inhibitor of… [PMID: 22764122]

     Laboratory literature summary: Targeting oncology research models proliferation with a small-molecule inhibitor of AICAR transformylase homodimerization. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

152. Longnus SL et al. (2003). 5-Aminoimidazole-4-carboxamide 1-beta -D-ribofuranoside (AICAR) stimulates myocardial… [PMID: 12626360]

     Laboratory literature summary: 5-Aminoimidazole-4-carboxamide 1-beta -D-ribofuranoside (AICAR) stimulates myocardial glycogenolysis by allosteric mechanisms. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

153. Wang HM et al. (2008). AICAR positively regulate glycogen synthase activity and LDL receptor expression… [PMID: 17945190]

     Laboratory literature summary: AICAR positively regulate glycogen synthase activity and LDL receptor expression through Raf-1/MEK/p42/44MAPK/p90RSK/GSK-3 signaling cascade. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

154. Wolan DW et al. (2003). Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor… [PMID: 12974624]

     Laboratory literature summary: Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor beta-DADF identifies the folate binding site. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

155. Wall M et al. (1999). A multisubstrate adduct inhibitor of AICAR transformylase [PMID: 10479275]

     Laboratory literature summary: A multisubstrate adduct inhibitor of AICAR transformylase. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

156. Ivarsson N et al. (2011). AICAR reverses ketone body mediated insulin resistance in isolated oxidative muscle [PMID: 21982775]

     Laboratory literature summary: AICAR reverses ketone body mediated insulin resistance in isolated oxidative muscle. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

157. LaRosa C et al. (2005). MEK inhibitors block AICAR-induced maturation in mouse oocytes by a MAPK-independent… [PMID: 15570612]

     Laboratory literature summary: MEK inhibitors block AICAR-induced maturation in mouse oocytes by a MAPK-independent mechanism. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

158. Giri S et al. (2006). AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations… [PMID: 16901342]

     Laboratory literature summary: AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced metabolic research models mice model. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

159. Cerveró C et al. (2016). Chronic investigation with the AMPK Agonist AICAR Prevents Skeletal Muscle Pathology… [PMID: 26582176]

     Laboratory literature summary: Chronic investigation with the AMPK Agonist AICAR Prevents Skeletal Muscle Pathology but Fails to Improve laboratory Outcome in a Mouse…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

160. Guan TJ et al. (2007). AICAR inhibits proliferation and induced S-phase arrest, and promotes apoptosis in… [PMID: 18031613]

     Laboratory literature summary: AICAR inhibits proliferation and induced S-phase arrest, and promotes apoptosis in CaSki cells. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

161. Habinowski SA et al. (2001). The effects of AICAR on adipocyte differentiation of 3T3-L1 cells [PMID: 11527376]

     Laboratory literature summary: The effects of AICAR on adipocyte differentiation of 3T3-L1 cells. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

162. Al-Khalili L et al. (2004). Prior serum- and AICAR-induced AMPK activation in primary research subjects myocytes… [PMID: 15149951]

     Laboratory literature summary: Prior serum- and AICAR-induced AMPK activation in primary research subjects myocytes does not lead to subsequent increase in…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

163. Chen Q et al. (2017). A Tbc1d1 (Ser231Ala)-knockin mutation partially impairs AICAR- but not… [PMID: 27826658]

     Laboratory literature summary: A Tbc1d1 (Ser231Ala)-knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

164. Wall M et al. (2000). Research subjects AICAR transformylase: role of the 4-carboxamide of AICAR in binding… [PMID: 10985775]

     Laboratory literature summary: research subjects AICAR transformylase: role of the 4-carboxamide of AICAR in binding and catalysis. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

165. Shen C et al. (2016). Metformin and AICAR regulate NANOG expression via the JNK pathway in HepG2 cells… [PMID: 26939902]

     Laboratory literature summary: Metformin and AICAR regulate NANOG expression via the JNK pathway in HepG2 cells independently of AMPK. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

166. Guo D et al. (2009). The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by… [PMID: 19625624]

     Laboratory literature summary: The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

167. Anthony NM et al. (2009). Laboratory research record on AICAR [PMID: 19214174]

     PubMed laboratory record discussing AICAR in a research context. Review the full methods and limitations on PubMed; research use only.

168. Bosselaar M et al. (2011). Intravenous AICAR during hyperinsulinemia induces systemic hemodynamic changes but has… [PMID: 21148051]

     Laboratory literature summary: Intravenous AICAR during hyperinsulinemia induces systemic hemodynamic changes but has no local metabolic effect. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

169. Fox M et al. (1993). AICAR is not an endogenous mutagen in Escherichia coli [PMID: 8413184]

     Laboratory literature summary: AICAR is not an endogenous mutagen in Escherichia coli. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

170. Wright C et al. (2017). Anti-Tumorigenic Potential of a Novel Orlistat-AICAR Combination in Prostate oncology… [PMID: 28387458]

     Laboratory literature summary: Anti-Tumorigenic Potential of a Novel Orlistat-AICAR Combination in Prostate oncology research models Cells. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

171. Choi RH et al. (2019). Adipose tissue-specific knockout of AMPKα1/α2 results in normal AICAR tolerance and… [PMID: 31540695]

     Laboratory literature summary: Adipose tissue-specific knockout of AMPKα1/α2 results in normal AICAR tolerance and glucose metabolism. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

172. Thomas A et al. (2013). Quantification of AICAR-ribotide concentrations in red blood cells by means of LC-MS/MS [PMID: 23828211]

     Laboratory literature summary: Quantification of AICAR-ribotide concentrations in red blood cells by means of LC-MS/MS. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

173. Grigorash BB et al. (2018). [AICAR-Dependent Activation of AMPK Kinase Is Not Accompanied by G1/S Block in Mouse… [PMID: 29989581]

     Laboratory literature summary: [AICAR-Dependent Activation of AMPK Kinase Is Not Accompanied by G1/S Block in Mouse Embryonic Stem Cells]. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

174. McConell GK et al. (2010). Central role of nitric oxide synthase in AICAR and caffeine-induced mitochondrial… [PMID: 20044477]

     Laboratory literature summary: Central role of nitric oxide synthase in AICAR and caffeine-induced mitochondrial biogenesis in L6 myocytes. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

175. Du JH et al. (2005). AICAR stimulates IL-6 production via p38 MAPK in cardiac fibroblasts in adult mice: a… [PMID: 16229818]

     Laboratory literature summary: AICAR stimulates IL-6 production via p38 MAPK in cardiac fibroblasts in adult mice: a possible role for AMPK. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

176. Zhuge J (2009). Overexpression of CYP2E1 induces HepG2 cells death by the AMP kinase activator… [PMID: 18473182]

     Laboratory literature summary: Overexpression of CYP2E1 induces HepG2 cells death by the AMP kinase activator 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

177. D'Errico S et al. (2015). Synthesis of 5-Aminoimidazole-4-Carboxamide Riboside (AICAR) and Its Derivatives Using… [PMID: 26623971]

     Laboratory literature summary: Synthesis of 5-Aminoimidazole-4-Carboxamide Riboside (AICAR) and Its Derivatives Using Inosine as Starting Material. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

178. Menze MA et al. (2010). Metabolic preconditioning of cells with AICAR-riboside: improved cryopreservation and… [PMID: 20510224]

     Laboratory literature summary: Metabolic preconditioning of cells with AICAR-riboside: improved cryopreservation and cell-type specific impacts on energetics and…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

179. Logie L et al. (2018). Regulation of hepatic glucose production and AMPK by AICAR but not by metformin… [PMID: 29962100]

     Laboratory literature summary: Regulation of hepatic glucose production and AMPK by AICAR but not by metformin depends on drug uptake through the equilibrative…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

180. Wang L et al. (2015). Wnt/β-Catenin mediates AICAR effect to increase GATA3 expression and inhibit adipogenesis [PMID: 26657755]

     Laboratory literature summary: Wnt/β-Catenin mediates AICAR effect to increase GATA3 expression and inhibit adipogenesis. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

181. Łabuzek K et al. (2010). AICAR (5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside) increases the… [PMID: 19853624]

     Laboratory literature summary: AICAR (5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside) increases the production of toxic molecules and affects the profile of…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

182. Adamo L et al. (2009). AICAR activates the pluripotency transcriptional network in embryonic stem cells and… [PMID: 19216758]

     Laboratory literature summary: AICAR activates the pluripotency transcriptional network in embryonic stem cells and induces KLF4 and KLF2 expression in fibroblasts. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

183. Chabowski A et al. (2005). The subcellular compartmentation of fatty acid transporters is regulated differently… [PMID: 15848183]

     Laboratory literature summary: The subcellular compartmentation of fatty acid transporters is regulated differently by insulin and by AICAR. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

184. Fodor T et al. (2016). Combined investigation of MCF-7 Cells with AICAR and Methotrexate, Arrests Cell Cycle… [PMID: 26919657]

     Laboratory literature summary: Combined investigation of MCF-7 Cells with AICAR and Methotrexate, Arrests Cell Cycle and Reverses Warburg Metabolism through…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

185. Martínez-Martín N et al. (2012). Metabolomics of the effect of AMPK activation by AICAR on research subjects umbilical… [PMID: 21956774]

     Laboratory literature summary: Metabolomics of the effect of AMPK activation by AICAR on research subjects umbilical vein endothelial cells. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

186. Hasenour CM et al. (2014). 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) effect on glucose… [PMID: 24403081]

     Laboratory literature summary: 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) effect on glucose production, but not energy metabolism, is independent of…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

187. Iglesias MA et al. (2002). AICAR administration causes an apparent enhancement of muscle and liver insulin action… [PMID: 12351423]

     Laboratory literature summary: AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

188. Knudsen JR et al. (2020). The ULK1/2 and AMPK Inhibitor SBI-0206965 Blocks AICAR and Insulin-Stimulated Glucose… [PMID: 32231045]

     Laboratory literature summary: The ULK1/2 and AMPK Inhibitor SBI-0206965 Blocks AICAR and Insulin-Stimulated Glucose Transport. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

189. Al-Moujahed A et al. (2014). Uveal melanoma cell growth is inhibited by aminoimidazole carboxamide ribonucleotide… [PMID: 24781943]

     Laboratory literature summary: Uveal melanoma cell growth is inhibited by aminoimidazole carboxamide ribonucleotide (AICAR) partially through activation of…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

190. Takemori H et al. (2009). Inactivation of HDAC5 by SIK1 in AICAR-studied C2C12 myoblasts [PMID: 18946175]

     Laboratory literature summary: Inactivation of HDAC5 by SIK1 in AICAR-studied C2C12 myoblasts. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

191. Shirai T et al. (2011). AICAR response element binding protein (AREBP), a key modulator of hepatic glucose… [PMID: 21910974]

     Laboratory literature summary: AICAR response element binding protein (AREBP), a key modulator of hepatic glucose production regulated by AMPK in vivo. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

192. Wan T et al. (2025). Laboratory research record on AICAR [PMID: 40082541]

     PubMed laboratory record discussing AICAR in a research context. Review the full methods and limitations on PubMed; research use only.

193. Houweling M et al. (2002). Regulation of phosphatidylcholine and phosphatidylethanolamine synthesis in rat… [PMID: 11829744]

     Laboratory literature summary: Regulation of phosphatidylcholine and phosphatidylethanolamine synthesis in rat hepatocytes by 5-aminoimidazole-4-carboxamide…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

194. Suwa M et al. (2003). Effects of chronic AICAR investigation on fiber composition, enzyme activity, UCP3,… [PMID: 12777406]

     Laboratory literature summary: Effects of chronic AICAR investigation on fiber composition, enzyme activity, UCP3, and PGC-1 in rat muscles. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

195. Tavassoli A et al. (2005). Genetically selected cyclic-peptide inhibitors of AICAR transformylase homodimerization [PMID: 15830403]

     Laboratory literature summary: Genetically selected cyclic-peptide inhibitors of AICAR transformylase homodimerization. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

196. Oki K et al. (2018). Prior investigation with the AMPK activator AICAR induces subsequently enhanced… [PMID: 29518344]

     Laboratory literature summary: Prior investigation with the AMPK activator AICAR induces subsequently enhanced glucose uptake in isolated skeletal muscles from…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

197. Ly P et al. (2013). Aneuploid research subjects colonic epithelial cells are sensitive to AICAR-induced… [PMID: 22890317]

     Laboratory literature summary: Aneuploid research subjects colonic epithelial cells are sensitive to AICAR-induced growth inhibition through EGFR degradation. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

198. Mentzer RM Jr et al. (1988). The acute effects of AICAR on purine nucleotide metabolism and postischemic cardiac… [PMID: 3339895]

     Laboratory literature summary: The acute effects of AICAR on purine nucleotide metabolism and postischemic cardiac function. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

199. Miyamoto L et al. (2013). AICAR stimulation metabolome widely mimics electrical contraction in isolated rat… [PMID: 24088893]

     Laboratory literature summary: AICAR stimulation metabolome widely mimics electrical contraction in isolated rat epitrochlearis muscle. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

200. Tsujimoto M et al. (2016). AICAR reduces the collagen-stimulated secretion of PDGF-AB and release of soluble CD40… [PMID: 27446328]

     Laboratory literature summary: AICAR reduces the collagen-stimulated secretion of PDGF-AB and release of soluble CD40 ligand from research subjects platelets:…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

201. Sengupta TK et al. (2007). Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) on… [PMID: 17623090]

     Laboratory literature summary: Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL)…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

202. Ford RJ et al. (2012). AMP-activated protein kinase activator AICAR acutely lowers blood pressure and relaxes… [PMID: 22306847]

     Laboratory literature summary: AMP-activated protein kinase activator AICAR acutely lowers blood pressure and relaxes isolated resistance arteries of hypertensive rats. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

203. Bazurto JV et al. (2017). Untargeted metabolomics confirms and extends the understanding of the impact of… [PMID: 29417056]

     Laboratory literature summary: Untargeted metabolomics confirms and extends the understanding of the impact of aminoimidazole carboxamide ribotide (AICAR) in the…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

204. Radika MK et al. (2015). Activation of insulin signaling and energy sensing network by AICAR, an AMPK activator… [PMID: 26124049]

     Laboratory literature summary: Activation of insulin signaling and energy sensing network by AICAR, an AMPK activator in insulin resistant rat tissues. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

205. Joy P et al. (2022). Case report of a rare purine synthesis disorder due to 5-aminoimidazole-4-carboxamide… [PMID: 35637059]

     Laboratory literature summary: Case report of a rare purine synthesis disorder due to 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICAR) deficiency. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

206. Fisher JS et al. (2005). Muscle contractions, AICAR, and insulin cause phosphorylation of an AMPK-related kinase [PMID: 16030062]

     Laboratory literature summary: Muscle contractions, AICAR, and insulin cause phosphorylation of an AMPK-related kinase. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

207. Xu P et al. (2011). AICAR and Compound C regulate food intake independently of AMP-activated protein… [PMID: 21530673]

     Laboratory literature summary: AICAR and Compound C regulate food intake independently of AMP-activated protein kinase in lines of chickens selected for high or low…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

208. Rantzau C et al. (2008). Contrasting effects of exercise, AICAR, and increased fatty acid supply on in vivo and… [PMID: 18032581]

     Laboratory literature summary: Contrasting effects of exercise, AICAR, and increased fatty acid supply on in vivo and skeletal muscle glucose metabolism. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

209. Kaushik VK et al. (2001). Regulation of fatty acid oxidation and glucose metabolism in rat soleus muscle:… [PMID: 11440910]

     Laboratory literature summary: Regulation of fatty acid oxidation and glucose metabolism in rat soleus muscle: effects of AICAR. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

210. Liu W et al. (2014). Depression-like behaviors in mice subjected to co-investigation of high-fat diet and… [PMID: 24388462]

     Laboratory literature summary: Depression-like behaviors in mice subjected to co-investigation of high-fat diet and corticosterone are ameliorated by AICAR and exercise. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

211. Delic V et al. (2018). The effects of AICAR and rapamycin on mitochondrial function in immortalized… [PMID: 30177551]

     Laboratory literature summary: The effects of AICAR and rapamycin on mitochondrial function in immortalized mitochondrial DNA mutator murine embryonic fibroblasts. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

212. Gualdoni GA et al. (2016). The AMP analog AICAR modulates the Treg/Th17 axis through enhancement of fatty acid… [PMID: 27492924]

     Laboratory literature summary: The AMP analog AICAR modulates the Treg/Th17 axis through enhancement of fatty acid oxidation. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

213. Sakamoto K et al. (2004). Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction,… [PMID: 15068958]

     Laboratory literature summary: Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

214. Kai Y et al. (2015). A possible role for AMP-activated protein kinase activated by metformin and AICAR in… [PMID: 25889494]

     Laboratory literature summary: A possible role for AMP-activated protein kinase activated by metformin and AICAR in research subjects granulosa cells. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

215. Iglesias MA et al. (2004). AMP-activated protein kinase activation by AICAR increases both muscle fatty acid and… [PMID: 15220186]

     Laboratory literature summary: AMP-activated protein kinase activation by AICAR increases both muscle fatty acid and glucose uptake in white muscle of…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

216. Chang MY et al. (2010). AICAR induces cyclooxygenase-2 expression through AMP-activated protein… [PMID: 20615388]

     Laboratory literature summary: AICAR induces cyclooxygenase-2 expression through AMP-activated protein kinase-transforming growth factor-beta-activated kinase 1-p38…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

217. Jørgensen SB et al. (2007). Role of AMPKalpha2 in basal, training-, and AICAR-induced GLUT4, hexokinase II, and… [PMID: 16954334]

     Laboratory literature summary: Role of AMPKalpha2 in basal, training-, and AICAR-induced GLUT4, hexokinase II, and mitochondrial protein expression in mouse muscle. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

218. Theodoropoulou S et al. (2013). Aminoimidazole carboxamide ribonucleotide (AICAR) inhibits the growth of… [PMID: 23300996]

     Laboratory literature summary: Aminoimidazole carboxamide ribonucleotide (AICAR) inhibits the growth of retinoblastoma in vivo by decreasing angiogenesis and inducing…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

219. Lemieux K et al. (2003). The AMP-activated protein kinase activator AICAR does not induce GLUT4 translocation… [PMID: 12958172]

     Laboratory literature summary: The AMP-activated protein kinase activator AICAR does not induce GLUT4 translocation to transverse tubules but stimulates glucose uptake…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

220. Chun MJ et al. (2017). Fanconi anemia protein FANCD2 is activated by AICAR, a modulator of AMPK and cellular… [PMID: 28174693]

     Laboratory literature summary: Fanconi anemia protein FANCD2 is activated by AICAR, a modulator of AMPK and cellular energy metabolism. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

221. Albert AP et al. (2008). AICAR decreases the activity of two distinct amiloride-sensitive Na+-permeable… [PMID: 18723760]

     Laboratory literature summary: AICAR decreases the activity of two distinct amiloride-sensitive Na+-permeable channels in H441 research subjects lung epithelial cell…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

222. Gaidhu MP et al. (2011). Chronic AMP-kinase activation with AICAR reduces adiposity by remodeling adipocyte… [PMID: 21737753]

     Laboratory literature summary: Chronic AMP-kinase activation with AICAR reduces adiposity by remodeling adipocyte metabolism and increasing leptin sensitivity. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

223. Ducommun S et al. (2014). Enhanced activation of cellular AMPK by dual-small molecule investigation: AICAR and… [PMID: 24425763]

     Laboratory literature summary: Enhanced activation of cellular AMPK by dual-small molecule investigation: AICAR and A769662. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

224. Gaidhu MP et al. (2010). Disruption of AMPKalpha1 signaling prevents AICAR-induced inhibition of AS160/TBC1D4… [PMID: 20501641]

     Laboratory literature summary: Disruption of AMPKalpha1 signaling prevents AICAR-induced inhibition of AS160/TBC1D4 phosphorylation and glucose uptake in primary rat…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

225. Cieslik KA et al. (2013). AICAR-dependent AMPK activation improves scar formation in the aged heart in a murine… [PMID: 23871790]

     Laboratory literature summary: AICAR-dependent AMPK activation improves scar formation in the aged heart in a murine model of reperfused myocardial infarction. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

226. Russell RR 3rd et al. (1999). Translocation of myocardial GLUT-4 and increased glucose uptake through activation of… [PMID: 10444490]

     Laboratory literature summary: Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

227. Wilcox SH et al. (2025). Chronic investigation of old mice with AICAR reverses age-related changes in exercise… [PMID: 40060947]

     Laboratory literature summary: Chronic investigation of old mice with AICAR reverses age-related changes in exercise performance and skeletal muscle gene expression. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

228. Wang W et al. (2016). Anti-inflammatory activities of fenoterol through β-arrestin-2 and inhibition of AMPK… [PMID: 27657826]

     Laboratory literature summary: Anti-inflammatory activities of fenoterol through β-arrestin-2 and inhibition of AMPK and NF-κB activation in AICAR-induced THP-1 cells. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

229. Smith JL et al. (2005). AICAR and hyperosmotic stress increase insulin-stimulated glucose transport [PMID: 15860681]

     Laboratory literature summary: AICAR and hyperosmotic stress increase insulin-stimulated glucose transport. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

230. Shibata T et al. (2013). Inhibition of the TNF-α-induced serine phosphorylation of IRS-1 at 636/639 by AICAR [PMID: 23698110]

     Laboratory literature summary: Inhibition of the TNF-α-induced serine phosphorylation of IRS-1 at 636/639 by AICAR. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

231. Péladeau C et al. (2016). Combinatorial investigational activation with heparin and AICAR stimulates additive… [PMID: 26494902]

     Laboratory literature summary: Combinatorial investigational activation with heparin and AICAR stimulates additive effects on utrophin A expression in dystrophic muscles. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

232. Gao J et al. (2018). The Adenosine Monophosphate (AMP) Analog, 5-Aminoimidazole-4-Carboxamide… [PMID: 30474622]

     Laboratory literature summary: The Adenosine Monophosphate (AMP) Analog, 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Inhibits Hepatosteatosis and Liver…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

233. Toedebusch RG et al. (2016). AMPK agonist AICAR delays the initial decline in lifetime-apex V̇o2 peak, while… [PMID: 26578698]

     Laboratory literature summary: AMPK agonist AICAR delays the initial decline in lifetime-apex V̇o2 peak, while voluntary wheel running fails to delay its initial…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

234. Suski M et al. (2017). The influence of AICAR – direct activator of AMP-activated protein kinase (AMPK) – on… [PMID: 28455001]

     Laboratory literature summary: The influence of AICAR – direct activator of AMP-activated protein kinase (AMPK) – on liver proteome in apoE-knockout mice. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

235. Abdul-Rahman O et al. (2016). AMP-Activated Kinase (AMPK) Activation by AICAR in research subjects White Adipocytes… [PMID: 27322180]

     Laboratory literature summary: AMP-Activated Kinase (AMPK) Activation by AICAR in research subjects White Adipocytes Derived from Pericardial White Adipose Tissue Stem…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

236. Pavlov TS et al. (2017). Lack of Effects of Metformin and AICAR Chronic Infusion on the Development of… [PMID: 28473772]

     Laboratory literature summary: Lack of Effects of Metformin and AICAR Chronic Infusion on the Development of Hypertension in Dahl Salt-Sensitive Rats. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

237. Daglioglu C et al. (2017). Investigational Effects of AICAR and DOX Conjugated Multifunctional Nanoparticles in… [PMID: 27783307]

     Laboratory literature summary: investigational Effects of AICAR and DOX Conjugated Multifunctional Nanoparticles in Sensitization and Elimination of oncology research…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

238. Albrecht D et al. (2016). Chemo-Genetic Interactions Between Histone Modification and the Antiproliferation Drug… [PMID: 27707786]

     Laboratory literature summary: Chemo-Genetic Interactions Between Histone Modification and the Antiproliferation Drug AICAR Are Conserved in Yeast and research subjects. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

239. Ryder JW et al. (2005). Effects of calcineurin activation on insulin-, AICAR- and contraction-induced glucose… [PMID: 15975979]

     Laboratory literature summary: Effects of calcineurin activation on insulin-, AICAR- and contraction-induced glucose transport in skeletal muscle. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

240. Mace OJ et al. (2008). AICAR activates AMPK and alters PIP2 association with the epithelial sodium channel… [PMID: 18669532]

     Laboratory literature summary: AICAR activates AMPK and alters PIP2 association with the epithelial sodium channel ENaC to inhibit Na+ transport in H441 lung…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

241. Gaidhu MP et al. (2012). Chronic AICAR-induced AMP-kinase activation regulates adipocyte lipolysis in a… [PMID: 23054058]

     Laboratory literature summary: Chronic AICAR-induced AMP-kinase activation regulates adipocyte lipolysis in a time-dependent and fat depot-specific manner in rats. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

242. Tadaishi M et al. (2011). Effect of exercise intensity and AICAR on isoform-specific expressions of murine… [PMID: 21098736]

     Laboratory literature summary: Effect of exercise intensity and AICAR on isoform-specific expressions of murine skeletal muscle PGC-1α mRNA: a role of β₂-adrenergic…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

243. Vitzel KF et al. (2013). Chronic investigation with the AMP-kinase activator AICAR increases glycogen storage… [PMID: 23620811]

     Laboratory literature summary: Chronic investigation with the AMP-kinase activator AICAR increases glycogen storage and fatty acid oxidation in skeletal muscles but…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

244. Lihn AS et al. (2008). Laboratory research record on AICAR [PMID: 18606210]

     PubMed laboratory record discussing AICAR in a research context. Review the full methods and limitations on PubMed; research use only.

245. Zajkowicz A et al. (2011). The activation of the p53 pathway by the AMP mimetic AICAR is reduced by inhibitors of… [PMID: 21945951]

     Laboratory literature summary: The activation of the p53 pathway by the AMP mimetic AICAR is reduced by inhibitors of the ATM or mTOR kinases. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

246. Frandsen N et al. (1993). Excess histidine enzymes cause AICAR-independent filamentation in Escherichia coli [PMID: 8413183]

     Laboratory literature summary: Excess histidine enzymes cause AICAR-independent filamentation in Escherichia coli. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

247. Jessen N et al. (2003). Effects of AICAR and exercise on insulin-stimulated glucose uptake, signaling, and… [PMID: 12496137]

     Laboratory literature summary: Effects of AICAR and exercise on insulin-stimulated glucose uptake, signaling, and GLUT-4 content in rat muscles. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

248. Van den Bergh F et al. (1993). Residual adenylosuccinase activities in fibroblasts of adenylosuccinase-deficient… [PMID: 8412002]

     Laboratory literature summary: Residual adenylosuccinase activities in fibroblasts of adenylosuccinase-deficient children: parallel deficiency with adenylosuccinate…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

249. Boon H et al. (2008). Laboratory research record on AICAR [PMID: 18709353]

     PubMed laboratory record discussing AICAR in a research context. Review the full methods and limitations on PubMed; research use only.

250. Inata Y et al. (2018). Age-dependent cardiac function during experimental sepsis: effect of pharmacological… [PMID: 29979626]

     Laboratory literature summary: Age-dependent cardiac function during experimental sepsis: effect of pharmacological activation of AMP-activated protein kinase by AICAR. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

251. Ayasolla KR et al. (2005). 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) attenuates the… [PMID: 16174294]

     Laboratory literature summary: 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) attenuates the expression of LPS- and Abeta peptide-induced inflammatory…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

252. Sell H et al. (2006). Cytokine secretion by research subjects adipocytes is differentially regulated by… [PMID: 16563350]

     Laboratory literature summary: Cytokine secretion by research subjects adipocytes is differentially regulated by adiponectin, AICAR, and troglitazone. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

253. Cosseau C et al. (2002). The fixM flavoprotein modulates inhibition by AICAR or 5'AMP of respiratory and… [PMID: 12059108]

     Laboratory literature summary: The fixM flavoprotein modulates inhibition by AICAR or 5'AMP of respiratory and nitrogen fixation gene expression in Sinorhizobium meliloti. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

254. Liang S et al. (2018). Preclinical evidence of the enhanced effectiveness of combined rapamycin and AICAR in… [PMID: 30107094]

     Laboratory literature summary: Preclinical evidence of the enhanced effectiveness of combined rapamycin and AICAR in reducing kidney oncology research models. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

255. Guo H et al. (2010). Suppression effects of AICAR on insulin secretion involved in peroxisome… [PMID: 20101096]

     Laboratory literature summary: Suppression effects of AICAR on insulin secretion involved in peroxisome proliferator-activated receptor gamma changes in INS-1 cells. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

256. Walker J et al. (2005). 5-aminoimidazole-4-carboxamide riboside (AICAR) enhances GLUT2-dependent jejunal… [PMID: 15367103]

     Laboratory literature summary: 5-aminoimidazole-4-carboxamide riboside (AICAR) enhances GLUT2-dependent jejunal glucose transport: a possible role for AMPK. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

257. Smith AC et al. (2005). AMP kinase activation with AICAR simultaneously increases fatty acid and glucose… [PMID: 15774530]

     Laboratory literature summary: AMP kinase activation with AICAR simultaneously increases fatty acid and glucose oxidation in resting rat soleus muscle. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

258. Taylor EB et al. (2008). Discovery of TBC1D1 as an insulin-, AICAR-, and contraction-stimulated signaling nexus… [PMID: 18276596]

     Laboratory literature summary: Discovery of TBC1D1 as an insulin-, AICAR-, and contraction-stimulated signaling nexus in mouse skeletal muscle. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

259. Lauritzen HP et al. (2013). Contraction and AICAR stimulate IL-6 vesicle depletion from skeletal muscle fibers in vivo [PMID: 23761105]

     Laboratory literature summary: Contraction and AICAR stimulate IL-6 vesicle depletion from skeletal muscle fibers in vivo. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

260. Foley JM et al. (1989). Utility of AICAr for metabolic studies is diminished by systemic effects in situ [PMID: 2782392]

     Laboratory literature summary: Utility of AICAr for metabolic studies is diminished by systemic effects in situ. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

261. Pan QR et al. (2009). Glucose, metformin, and AICAR regulate the expression of G protein-coupled receptor… [PMID: 19672815]

     Laboratory literature summary: Glucose, metformin, and AICAR regulate the expression of G protein-coupled receptor members in INS-1 beta cell. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

262. Kramer HF et al. (2006). Distinct signals regulate AS160 phosphorylation in response to insulin, AICAR, and… [PMID: 16804077]

     Laboratory literature summary: Distinct signals regulate AS160 phosphorylation in response to insulin, AICAR, and contraction in mouse skeletal muscle. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

263. Daignan-Fornier B et al. (2012). 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-Monophosphate (AICAR), a… [PMID: 24957512]

     Laboratory literature summary: 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-Monophosphate (AICAR), a Highly Conserved Purine Intermediate with Multiple Effects. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

264. Malykh EA et al. (2018). Specific features of L-histidine production by Escherichia coli concerned with… [PMID: 29544475]

     Laboratory literature summary: Specific features of L-histidine production by Escherichia coli concerned with feedback control of AICAR formation and inorganic…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

265. Russe OQ et al. (2014). LPS inhibits caspase 3-dependent apoptosis in RAW264.7 macrophages induced by the AMPK… [PMID: 24732361]

     Laboratory literature summary: LPS inhibits caspase 3-dependent apoptosis in RAW264.7 macrophages induced by the AMPK activator AICAR. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

266. Ai H et al. (2002). Effect of fiber type and nutritional state on AICAR- and contraction-stimulated… [PMID: 12006359]

     Laboratory literature summary: Effect of fiber type and nutritional state on AICAR- and contraction-stimulated glucose transport in rat muscle. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

267. Ojuka EO et al. (2000). Increased expression of GLUT-4 and hexokinase in rat epitrochlearis muscles exposed to… [PMID: 10710405]

     Laboratory literature summary: Increased expression of GLUT-4 and hexokinase in rat epitrochlearis muscles exposed to AICAR in vitro. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

268. Ford RJ et al. (2011). Endothelium-dependent vasorelaxation to the AMPK activator AICAR is enhanced in aorta… [PMID: 20971768]

     Laboratory literature summary: Endothelium-dependent vasorelaxation to the AMPK activator AICAR is enhanced in aorta from hypertensive rats and is NO and EDCF dependent. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

269. Shim JH et al. (2001). Evaluation of the catalytic mechanism of AICAR transformylase by pH-dependent… [PMID: 11457277]

     Laboratory literature summary: Evaluation of the catalytic mechanism of AICAR transformylase by pH-dependent kinetics, mutagenesis, and quantum chemical calculations. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

270. Chadt A et al. (2015). “Deletion of both Rab-GTPase–activating proteins TBC1D1 and TBC1D4 in mice eliminates… [PMID: 25249576]

     Laboratory literature summary: “Deletion of both Rab-GTPase–activating proteins TBC1D1 and TBC1D4 in mice eliminates insulin- and AICAR-stimulated glucose transport…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

271. Suzuki J et al. (2011). Inhibitory effect of aminoimidazole carboxamide ribonucleotide (AICAR) on… [PMID: 21775660]

     Laboratory literature summary: Inhibitory effect of aminoimidazole carboxamide ribonucleotide (AICAR) on endotoxin-induced uveitis in rats. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

272. Montraveta A et al. (2014). Synergistic anti-oncology research models activity of acadesine (AICAR) in combination… [PMID: 24519895]

     Laboratory literature summary: Synergistic anti-oncology research models activity of acadesine (AICAR) in combination with the anti-CD20 monoclonal antibody rituximab…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

273. Young ME et al. (1996). Activation of glycogen phosphorylase and glycogenolysis in rat skeletal muscle by… [PMID: 8612761]

     Laboratory literature summary: Activation of glycogen phosphorylase and glycogenolysis in rat skeletal muscle by AICAR–an activator of AMP-activated protein kinase. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

274. Babraj JA et al. (2009). Laboratory research record on AICAR [PMID: 19190259]

     PubMed laboratory record discussing AICAR in a research context. Review the full methods and limitations on PubMed; research use only.

275. Sauer H et al. (2012). Activation of AMP-kinase by AICAR induces apoptosis of DU-145 prostate oncology… [PMID: 22002081]

     Laboratory literature summary: Activation of AMP-kinase by AICAR induces apoptosis of DU-145 prostate oncology research models cells through generation of reactive…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

276. Lee KC et al. (2017). Effect of AICAR and 5-Fluorouracil on X-ray Repair, Cross-Complementing Group 1… [PMID: 29117108]

     Laboratory literature summary: Effect of AICAR and 5-Fluorouracil on X-ray Repair, Cross-Complementing Group 1 Expression, and Consequent Cytotoxicity Regulation in…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

277. Geraghty KM et al. (2007). Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to… [PMID: 17617058]

     Laboratory literature summary: Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

278. Halseth AE et al. (2002). Acute and chronic investigation of ob/ob and db/db mice with AICAR decreases blood… [PMID: 12061777]

     Laboratory literature summary: Acute and chronic investigation of ob/ob and db/db mice with AICAR decreases blood glucose concentrations. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

279. Balon TW et al. (2001). Acute exposure to AICAR increases glucose transport in mouse EDL and soleus muscle [PMID: 11352652]

     Laboratory literature summary: Acute exposure to AICAR increases glucose transport in mouse EDL and soleus muscle. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

280. Sui X et al. (2014). Use of metformin alone is not associated with survival outcomes of colorectal oncology… [PMID: 24849329]

     Laboratory literature summary: Use of metformin alone is not associated with survival outcomes of colorectal oncology research models cell but AMPK activator AICAR…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

281. Frier BC et al. (2012). Epinephrine and AICAR-induced PGC-1α mRNA expression is intact in skeletal muscle from… [PMID: 22496244]

     Laboratory literature summary: Epinephrine and AICAR-induced PGC-1α mRNA expression is intact in skeletal muscle from rats fed a high-fat diet. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

282. Bumpus NN et al. (2011). 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression… [PMID: 21896918]

     Laboratory literature summary: 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

283. Pauly M et al. (2015). Combined Strategies for Maintaining Skeletal Muscle Mass and Function in Aging:… [PMID: 25227129]

     Laboratory literature summary: Combined Strategies for Maintaining Skeletal Muscle Mass and Function in Aging: Myostatin Inactivation and AICAR-Associated Oxidative…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

284. Yan X et al. (2026). AMPK activation by AICAR mitigates hypoxic corneal damage through rebuilding energy… [PMID: 42392248]

     Laboratory literature summary: AMPK activation by AICAR mitigates hypoxic corneal damage through rebuilding energy and metabolic homeostasis. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

285. Rosilio C et al. (2013). The metabolic perturbators metformin, phenformin and AICAR interfere with the growth… [PMID: 23612073]

     Laboratory literature summary: The metabolic perturbators metformin, phenformin and AICAR interfere with the growth and survival of murine PTEN-deficient T cell…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

286. Bikman BT et al. (2010). Laboratory research record on AICAR [PMID: 20393162]

     PubMed laboratory record discussing AICAR in a research context. Review the full methods and limitations on PubMed; research use only.

287. Brandauer J et al. (2015). AMP-activated protein kinase controls exercise training- and AICAR-induced increases… [PMID: 25852572]

     Laboratory literature summary: AMP-activated protein kinase controls exercise training- and AICAR-induced increases in SIRT3 and MnSOD. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

288. Lobanov KV et al. (2011). Reconstruction of Purine Metabolism in Bacillus subtilis to Obtain the Strain Producer… [PMID: 22649686]

     Laboratory literature summary: Reconstruction of Purine Metabolism in Bacillus subtilis to Obtain the Strain Producer of AICAR: A New Drug with a Wide Range of…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

289. Xi L et al. (2012). The effect of 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) on fatty acid… [PMID: 23072465]

     Laboratory literature summary: The effect of 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) on fatty acid oxidation in hepatocytes isolated from neonatal piglets. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

290. Kim JE et al. (2008). AMP-activated protein kinase activation by… [PMID: 18360094]

     Laboratory literature summary: AMP-activated protein kinase activation by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) inhibits palmitate-induced…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

291. Langelueddecke C et al. (2012). Effect of the AMP-kinase modulators AICAR, metformin and compound C on insulin… [PMID: 22415077]

     Laboratory literature summary: Effect of the AMP-kinase modulators AICAR, metformin and compound C on insulin secretion of INS-1E rat insulinoma cells under standard…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

292. Kim WH et al. (2007). AICAR potentiates ROS production induced by chronic high glucose: roles of AMPK in… [PMID: 17127032]

     Laboratory literature summary: AICAR potentiates ROS production induced by chronic high glucose: roles of AMPK in pancreatic beta-cell apoptosis. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

293. Bultot L et al. (2016). Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake… [PMID: 27577855]

     Laboratory literature summary: Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

294. Ducommun S et al. (2012). Thr649Ala-AS160 knock-in mutation does not impair contraction/AICAR-induced glucose… [PMID: 22318952]

     Laboratory literature summary: Thr649Ala-AS160 knock-in mutation does not impair contraction/AICAR-induced glucose transport in mouse muscle. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

295. Jørgensen SB et al. (2009). Oligomeric resistin impairs insulin and AICAR-stimulated glucose uptake in mouse… [PMID: 19435854]

     Laboratory literature summary: Oligomeric resistin impairs insulin and AICAR-stimulated glucose uptake in mouse skeletal muscle by inhibiting GLUT4 translocation. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

296. Jo K et al. (2021). Effect of Deer Antler Extract on Muscle Differentiation and… [PMID: 34291211]

     Laboratory literature summary: Effect of Deer Antler Extract on Muscle Differentiation and 5-Aminoimidazole-4-Carboxamide Ribonucleoside (AICAR)-Induced Muscle Atrophy…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

297. Takahashi K et al. (2026). AICAR improves depression-like behaviors and is associated with hippocampal AMPK… [PMID: 41932583]

     Laboratory literature summary: AICAR improves depression-like behaviors and is associated with hippocampal AMPK activation and modulation of neurogenesis and…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

298. Shang J et al. (2004). Activation of glycogen phosphorylase with 5-aminoimidazole-4-carboxamide riboside… [PMID: 14729664]

     Laboratory literature summary: Activation of glycogen phosphorylase with 5-aminoimidazole-4-carboxamide riboside (AICAR). Assessment of glycogen as a precursor of…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

299. Habib SL et al. (2016). Laboratory research record on AICAR [PMID: 27611085]

     PubMed laboratory record discussing AICAR in a research context. Review the full methods and limitations on PubMed; research use only.

300. Barthel A et al. (2002). Regulation of the forkhead transcription factor FKHR (FOXO1a) by glucose starvation… [PMID: 12130586]

     Laboratory literature summary: Regulation of the forkhead transcription factor FKHR (FOXO1a) by glucose starvation and AICAR, an activator of AMP-activated protein kinase. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

301. Bilodeau-Goeseels S et al. (2011). Activation of AMP-activated protein kinase may not be involved in AICAR- and… [PMID: 20569514]

     Laboratory literature summary: Activation of AMP-activated protein kinase may not be involved in AICAR- and metformin-mediated meiotic arrest in bovine denuded and…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

302. Smith AC et al. (2005). AMP kinase activation with AICAR further increases fatty acid oxidation and blunts… [PMID: 15774529]

     Laboratory literature summary: AMP kinase activation with AICAR further increases fatty acid oxidation and blunts triacylglycerol hydrolysis in contracting rat soleus…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

303. Liu J et al. (2013). Analysis of microRNA expression profile induced by AICAR in mouse hepatocytes [PMID: 23107762]

     Laboratory literature summary: Analysis of microRNA expression profile induced by AICAR in mouse hepatocytes. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

304. McConell GK et al. (2008). Differential attenuation of AMPK activation during acute exercise following exercise… [PMID: 18703760]

     Laboratory literature summary: Differential attenuation of AMPK activation during acute exercise following exercise training or AICAR investigation. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

305. Boger DL et al. (1998). Design, synthesis, and evaluation of potential GAR and AICAR transformylase inhibitors [PMID: 9681131]

     Laboratory literature summary: Design, synthesis, and evaluation of potential GAR and AICAR transformylase inhibitors. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

306. Chen HC et al. (2002). Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and… [PMID: 11978788]

     Laboratory literature summary: Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

307. Yu X et al. (2004). Laboratory research record on AICAR [PMID: 15578153]

     PubMed laboratory record discussing AICAR in a research context. Review the full methods and limitations on PubMed; research use only.

308. Bulusu V et al. (2011). Mechanism of growth inhibition of intraerythrocytic stages of Plasmodium falciparum by… [PMID: 21251933]

     Laboratory literature summary: Mechanism of growth inhibition of intraerythrocytic stages of Plasmodium falciparum by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR). Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

309. Miyatake S et al. (2014). Macrophage migration inhibitory factor diminishes muscle glucose transport induced by… [PMID: 24472542]

     Laboratory literature summary: Macrophage migration inhibitory factor diminishes muscle glucose transport induced by insulin and AICAR in a muscle type-dependent manner. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

310. Woollhead AM et al. (2005). Phenformin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR)… [PMID: 15919715]

     Laboratory literature summary: Phenformin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) activation of AMP-activated protein kinase inhibits…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

311. Solskov L et al. (2012). Microarray expression analysis in delayed cardioprotection: the effect of exercise,… [PMID: 21964537]

     Laboratory literature summary: Microarray expression analysis in delayed cardioprotection: the effect of exercise, AICAR, or metformin and the possible role of…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

312. Qin S et al. (2008). Implication of S-adenosylhomocysteine hydrolase in inhibition of TNF-alpha- and… [PMID: 18326758]

     Laboratory literature summary: Implication of S-adenosylhomocysteine hydrolase in inhibition of TNF-alpha- and IL-1beta-induced expression of inflammatory mediators by…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

313. Sah S et al. (2018). Utilisation of 10-formyldihydrofolate as substrate by dihydrofolate reductase (DHFR)… [PMID: 29799386]

     Laboratory literature summary: Utilisation of 10-formyldihydrofolate as substrate by dihydrofolate reductase (DHFR) and 5-aminoimidazole-4-carboxamide ribonucleotide…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

314. Fan X et al. (2009). Laboratory research record on AICAR [PMID: 19357294]

     PubMed laboratory record discussing AICAR in a research context. Review the full methods and limitations on PubMed; research use only.

315. Bamford JA et al. (2003). Effects of chronic AICAR administration on the metabolic and contractile phenotypes of… [PMID: 14719043]

     Laboratory literature summary: Effects of chronic AICAR administration on the metabolic and contractile phenotypes of rat slow- and fast-twitch skeletal muscles. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

316. Frier BC et al. (2011). Reductions in RIP140 are not required for exercise- and AICAR-mediated increases in… [PMID: 21700896]

     Laboratory literature summary: Reductions in RIP140 are not required for exercise- and AICAR-mediated increases in skeletal muscle mitochondrial content. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

317. Park S et al. (2011). Chronic high cytosolic calcium decreases AICAR-induced AMPK activity via… [PMID: 21641034]

     Laboratory literature summary: Chronic high cytosolic calcium decreases AICAR-induced AMPK activity via calcium/calmodulin activated protein kinase II signaling cascade. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

318. Williamson DL et al. (2006). Time course changes in signaling pathways and protein synthesis in C2C12 myotubes… [PMID: 16760336]

     Laboratory literature summary: Time course changes in signaling pathways and protein synthesis in C2C12 myotubes following AMPK activation by AICAR. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

319. Sullivan JE et al. (1994). Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a… [PMID: 7926017]

     Laboratory literature summary: Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

320. Nystrom GJ et al. (2008). Sepsis and AMPK Activation by AICAR Differentially Regulate FoxO-1, -3 and -4 mRNA in… [PMID: 19079687]

     Laboratory literature summary: Sepsis and AMPK Activation by AICAR Differentially Regulate FoxO-1, -3 and -4 mRNA in Striated Muscle. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

321. Boger DL et al. (1997). Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of GAR Tfase… [PMID: 9354238]

     Laboratory literature summary: Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of GAR Tfase or AICAR Tfase. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

322. Chadt A et al. (2015). Laboratory research record on AICAR [PMID: 25805765]

     PubMed laboratory record discussing AICAR in a research context. Review the full methods and limitations on PubMed; research use only.

323. Daglioglu C et al. (2016). Synthesis and Characterization of AICAR and DOX Conjugated Multifunctional… [PMID: 26996194]

     Laboratory literature summary: Synthesis and Characterization of AICAR and DOX Conjugated Multifunctional Nanoparticles as a Platform for Synergistic Inhibition of…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

324. Diraison F et al. (2004). Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat… [PMID: 14690455]

     Laboratory literature summary: Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

325. Sala-Icardo L et al. (2017). Impact of genetic variants of ATP binding cassette B1, AICAR transformylase/IMP… [PMID: 27751863]

     Laboratory literature summary: Impact of genetic variants of ATP binding cassette B1, AICAR transformylase/IMP cyclohydrolase, folyl-polyglutamatesynthetase, and…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

326. D'Errico S et al. (2011). Solid-phase synthesis of a new diphosphate 5-aminoimidazole-4-carboxamide riboside… [PMID: 21937970]

     Laboratory literature summary: Solid-phase synthesis of a new diphosphate 5-aminoimidazole-4-carboxamide riboside (AICAR) derivative and studies toward cyclic AICAR…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

327. Golubitzky A et al. (2011). Screening for active small molecules in mitochondrial complex I deficient research… [PMID: 22046392]

     Laboratory literature summary: Screening for active small molecules in mitochondrial complex I deficient research subjects's fibroblasts, reveals AICAR as the most…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

328. Thomson DM et al. (2009). AMP-activated protein kinase response to contractions and investigation with the AMPK… [PMID: 19273578]

     Laboratory literature summary: AMP-activated protein kinase response to contractions and investigation with the AMPK activator AICAR in young adult and old skeletal muscle. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

329. Capps KJ et al. (2005). Discovery of AICAR Tfase inhibitors that disrupt requisite enzyme dimerization [PMID: 15911265]

     Laboratory literature summary: Discovery of AICAR Tfase inhibitors that disrupt requisite enzyme dimerization. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

330. Dokas J et al. (2013). Conventional knockout of Tbc1d1 in mice impairs insulin- and AICAR-stimulated glucose… [PMID: 23892475]

     Laboratory literature summary: Conventional knockout of Tbc1d1 in mice impairs insulin- and AICAR-stimulated glucose uptake in skeletal muscle. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

331. Flores A et al. (1993). The pleiotropic effects of his overexpression in Salmonella typhimurium do not involve… [PMID: 8413185]

     Laboratory literature summary: The pleiotropic effects of his overexpression in Salmonella typhimurium do not involve AICAR-induced mutagenesis. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

332. Boger DL et al. (1997). Functionalized analogues of 5,8,10-trideazafolate: development of an enzyme-assembled… [PMID: 9354239]

     Laboratory literature summary: Functionalized analogues of 5,8,10-trideazafolate: development of an enzyme-assembled tight binding inhibitor of GAR Tfase and a…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

333. Christopher M et al. (2006). Impact of in vivo fatty acid oxidation blockade on glucose turnover and muscle glucose… [PMID: 16772328]

     Laboratory literature summary: Impact of in vivo fatty acid oxidation blockade on glucose turnover and muscle glucose metabolism during low-exposure level AICAR infusion. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

334. Mauser M et al. (1985). Influence of ribose, adenosine, and "AICAR" on the rate of myocardial adenosine… [PMID: 3918804]

     Laboratory literature summary: Influence of ribose, adenosine, and "AICAR" on the rate of myocardial adenosine triphosphate synthesis during reperfusion after coronary…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

335. Hoffmeister HM et al. (1985). Effect of adenosine and AICAR on ATP content and regional contractile function in… [PMID: 4051946]

     Laboratory literature summary: Effect of adenosine and AICAR on ATP content and regional contractile function in reperfused canine myocardium. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

336. Costanzi S et al. (2005). Ring opening reactions: synthesis of AICAR analogs as potential antimetabolite agents [PMID: 16247961]

     Laboratory literature summary: Ring opening reactions: synthesis of AICAR analogs as potential antimetabolite agents. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

337. Menassol JB et al. (2011). The effect of an intracerebroventricular parenteral-route administration of metformin… [PMID: 21801416]

     Laboratory literature summary: The effect of an intracerebroventricular parenteral-route administration of metformin or AICAR on the plasma concentrations of melatonin…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

338. Clough-Helfman C et al. (1990). 5-Aminoimidazole-4-carboxamide riboside (AICAr) administration reduces cerebral… [PMID: 2207710]

     Laboratory literature summary: 5-Aminoimidazole-4-carboxamide riboside (AICAr) administration reduces cerebral ischemic damage in the Mongolian gerbil. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

339. Florant GL et al. (2010). To eat or not to eat: the effect of AICAR on food intake regulation in yellow-bellied… [PMID: 20511516]

     Laboratory literature summary: To eat or not to eat: the effect of AICAR on food intake regulation in yellow-bellied marmots (Marmota flaviventris). Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

340. Dagher Z et al. (1999). The effect of AMP-activated protein kinase and its activator AICAR on the metabolism… [PMID: 10548499]

     Laboratory literature summary: The effect of AMP-activated protein kinase and its activator AICAR on the metabolism of research subjects umbilical vein endothelial cells. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

341. Bonen A et al. (2007). A null mutation in skeletal muscle FAT/CD36 reveals its essential role in insulin- and… [PMID: 17264223]

     Laboratory literature summary: A null mutation in skeletal muscle FAT/CD36 reveals its essential role in insulin- and AICAR-stimulated fatty acid metabolism. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

342. Axelrod HL et al. (2008). Crystal structure of AICAR transformylase IMP cyclohydrolase (TM1249) from Thermotoga… [PMID: 18260100]

     Laboratory literature summary: Crystal structure of AICAR transformylase IMP cyclohydrolase (TM1249) from Thermotoga maritima at 1.88 A resolution. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

343. Torsti T et al. (2026). Thapsigargin-induced autophagic flux impairment and inflammation are potentiated by… [PMID: 42308764]

     Laboratory literature summary: Thapsigargin-induced autophagic flux impairment and inflammation are potentiated by CLN3 deficiency and alleviated by…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

344. Marsilje TH et al. (2003). Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle,… [PMID: 13129585]

     Laboratory literature summary: Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

345. Hoogendijk AJ et al. (2013). AMP-activated protein kinase activation by… [PMID: 23322781]

     Laboratory literature summary: AMP-activated protein kinase activation by 5-aminoimidazole-4-carbox-amide-1-β-D-ribofuranoside (AICAR) reduces lipoteichoic…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

346. Alenazi FSH et al. (2015). Estradiol Regulates Dorsal Vagal Complex Signal Transduction Pathway Transcriptional… [PMID: 25796381]

     Laboratory literature summary: Estradiol Regulates Dorsal Vagal Complex Signal Transduction Pathway Transcriptional Reactivity to the AMPK Activator…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

347. D'Errico S et al. (2012). A facile synthesis of 5'-fluoro-5'-deoxyacadesine (5'-F-AICAR): a novel… [PMID: 23124472]

     Laboratory literature summary: A facile synthesis of 5'-fluoro-5'-deoxyacadesine (5'-F-AICAR): a novel non-phosphorylable AICAR analogue. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

348. Arakawa T et al. (1966). Aminoimidazolecarboxamide ribotide (AICAR)-transformylase of erythrocytes in… [PMID: 5955239]

     Laboratory literature summary: Aminoimidazolecarboxamide ribotide (AICAR)-transformylase of erythrocytes in formiminotransferase deficiency syndrome. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

349. Man HM et al. (2001). Increased glutamine synthetase activity and changes in amino acid pools in leaves… [PMID: 11240912]

     Laboratory literature summary: Increased glutamine synthetase activity and changes in amino acid pools in leaves studied with 5-aminoimidazole-4-carboxiamide…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

350. Leclerc GM et al. (2010). AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and… [PMID: 20863384]

     Laboratory literature summary: AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

351. Kanno Y et al. (2010). 5-aminoimidazole-4-carboxamide-1-beta-ribofuranoside (AICAR) prevents nuclear… [PMID: 20686344]

     Laboratory literature summary: 5-aminoimidazole-4-carboxamide-1-beta-ribofuranoside (AICAR) prevents nuclear translocation of constitutive androstane receptor by…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

352. Marsilje TH et al. (2003). 10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a… [PMID: 13129586]

     Laboratory literature summary: 10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

353. Ujjinamatada RK et al. (2007). An analogue of AICAR with dual inhibitory activity against WNV and HCV… [PMID: 17289387]

     Laboratory literature summary: An analogue of AICAR with dual inhibitory activity against WNV and HCV NTPase/helicase: synthesis and in vitro screening of…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

354. Soberón M et al. (1997). Genetic evidence for 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) as a… [PMID: 9202382]

     Laboratory literature summary: Genetic evidence for 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) as a negative effector of cytochrome terminal oxidase cbb3…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

355. Boger DL et al. (2000). Design, synthesis, and biological evaluation of fluoronitrophenyl substituted folate… [PMID: 10888335]

     Laboratory literature summary: Design, synthesis, and biological evaluation of fluoronitrophenyl substituted folate analogues as potential inhibitors of GAR…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

356. Kim JW et al. (2008). Transcriptional mechanism of suppression of insulin gene expression by AMP-activated… [PMID: 18035054]

     Laboratory literature summary: Transcriptional mechanism of suppression of insulin gene expression by AMP-activated protein kinase activator…. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

357. Barthel A et al. (2002). Regulation of the Forkhead Transcription Factor FKHR (FOXO1a) by Glucose Starvation… [PMID: 28201650]

     Laboratory literature summary: Regulation of the Forkhead Transcription Factor FKHR (FOXO1a) by Glucose Starvation and AICAR, an Activator of AMP-Activated Protein Kinase. Consult the PubMed record for methods, models, and limitations. Presented for research literature review only

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