5-Amino-1MQ is an orally bioavailable, cell-permeable small molecule that potently inhibits NNMT (nicotinamide N-methyltransferase), the enzyme responsible for methylating nicotinamide to 1-methylnicotinamide (1-MNA). By blocking NNMT, 5-Amino-1MQ modulates intracellular NAD+ pools and related metabolic pathways. Research in preclinical models has explored its role in NNMT inhibition, NAD+ metabolism, and cellular energetics (pmc.ncbi.nlm.nih.gov, pubmed.ncbi.nlm.nih.gov). This research-grade crystalline powder is produced under strict quality controls and provided with full analytical documentation.
For Research Use Only. Not for human use.
Key Scientific Attributes
- High-purity 5-Amino-1MQ (≥ 99% by HPLC/MS)
- Verified structure: 5-amino-1-methylquinolinium
- Crystalline powder for long-term stability
- Full Certificate of Analysis (COA) with HPLC, MS, NMR, and NNMT inhibition assay (IC₅₀ confirmation)
- Manufactured in GMP-aligned, ISO-compliant facilities
- Suitable for NNMT inhibition, NAD+ modulation, and metabolic pathway studies in laboratory settings
Research-Referenced Attributes (Based on scientific literature; not intended as therapeutic claims. For laboratory research use only.)
- Selective NNMT inhibitor with documented IC₅₀ values in preclinical biochemical assays (pmc.ncbi.nlm.nih.gov)
- Studied in diet-induced obese (DIO) mouse models for effects on adipose tissue and metabolic markers.
- Investigated for effects on NAD+ salvage pathway and mitochondrial metabolism in preclinical systems (rawamino.com)
- Subject of ongoing preclinical research in metabolic and oncology laboratory models
- Orally bioavailable small molecule; used in in vivo and in vitro research settings
Why Researchers Choose Our 5-Amino-1MQ
- Consistent with the material used in published NNMT inhibition research
- Transparent analytical data (HPLC >99%, NMR confirmation)
- Suitable for metabolic disease and oncology laboratory research
- Competitive research pricing with bulk options
For Research Use Only. Not for human or animal use. Not intended to diagnose, treat, cure, or prevent any disease or condition.
