For Research Use Only. Not for human use.
ACE-031 is a recombinant fusion protein originally developed as a clinical candidate. It functions as a soluble decoy receptor comprising the extracellular domain of the activin type IIB receptor (ActRIIB) fused to an IgG1-Fc region. It binds myostatin (GDF-8), activin A, and related TGF-β family ligands with high affinity, competitively inhibiting their interaction with endogenous ActRIIB receptors. This research-grade lyophilized protein is produced under strict quality controls and is provided with full analytical documentation for use in laboratory research settings.
Key Scientific Attributes
- High-purity ACE-031 (≥98% by HPLC/SEC, recombinant human sequence)
- Verified ActRIIB extracellular domain + IgG1-Fc fusion with correct disulfide bonding
- Lyophilized formulation for long-term stability under appropriate laboratory storage conditions
- Full Certificate of Analysis (COA) with HPLC, SEC, binding ELISA (myostatin/activin A), and endotoxin testing
- Manufactured in GMP-aligned, ISO-compliant facilities
- Suitable for in vitro myostatin/activin A blockade studies and neuromuscular pathway research models
Research-Referenced Attributes
- Potent myostatin/activin A sequestration activity as characterized in peer-reviewed scientific literature
- Mechanistic data available in published preclinical and clinical-phase research literature
- Well-characterized biochemical profile based on published human trial documentation
- Relevant to research areas including sarcopenia biology, cachexia mechanisms, and neuromuscular disease models (e.g., DMD)
Why Researchers Choose Nationwide Peptides ACE-031
- Sequence-verified match to the clinically studied ActRIIB-Fc construct
- High documented myostatin-binding affinity as confirmed by functional binding ELISA
- Transparent analytical data (HPLC/SEC >98%)
- Suitable for muscle physiology, neuromuscular disease, and regenerative biology laboratory investigations
- Competitive research pricing with bulk options available
This product is intended for laboratory and research use only. It is not intended for human or animal consumption, and is not a drug, supplement, or therapeutic product.
