MGF is the C-terminal splice variant of IGF-1 (also called IGF-1Ec) that is upregulated in muscle tissue following mechanical overload or damage. Unlike systemic IGF-1, MGF remains locally active, with preclinical studies indicating roles in satellite cell recruitment, myoblast proliferation, and differentiation timing in mechanically stimulated tissue. First characterized in research by Goldspink’s group, it is widely used in mechano-transduction and muscle biology studies. This research-grade lyophilized peptide is synthesized under strict quality controls and provided with full analytical documentation for use in laboratory research settings only.
For Research Use Only. Not for human use.
Key Scientific Attributes
- High-purity MGF (≥ 98% by HPLC/MS, acetate salt form)
- Verified 24-amino-acid sequence (human IGF-1Ec isoform)
- Lyophilized formulation for maximum long-term stability
- Full Certificate of Analysis (COA) with HPLC, MS, and amino acid analysis
- Manufactured in GMP-aligned, ISO-compliant facilities
- Suitable for satellite cell biology, local IGF-1 signaling studies, and mechanical loading research models
Research-Referenced Attributes (Based on scientific literature; not intended as therapeutic claims. For research use only.)
- Shown in preclinical models to be rapidly induced in muscle tissue after mechanical stretch or damage, functioning as a locally acting isoform of IGF-1 (pmc.ncbi.nlm.nih.gov)
- Studied for its role in satellite cell activation and myoblast proliferation kinetics in in vitro and in vivo research models (pmc.ncbi.nlm.nih.gov)
- Subject of preclinical investigations in skeletal muscle, cardiac, and neurological tissue research contexts (pmc.ncbi.nlm.nih.gov)
- Used in research exploring IGF-1 gene splice variant biology, including sarcopenia models, muscular dystrophy models, and neurological tissue models — strictly in laboratory settings
Why Researchers Choose This MGF
- Exact human IGF-1Ec (MGF) sequence used in published Goldspink studies
- Transparent analytical data (HPLC >98%, MS confirmation)
- Trusted by muscle physiology and mechano-transduction laboratories
- Competitive research pricing with bulk options
