IGF-1 DES (1-3) is a truncated analog of IGF-1 available for research purposes. By removing the N-terminal tripeptide (Gly-Pro-Glu), it exhibits significantly reduced affinity for IGF-binding proteins (IGFBPs), resulting in an ultra-short plasma half-life and increased potency at the IGF-1 receptor. First identified as a natural IGF-1 variant in brain tissue and colostrum, it is now used by researchers studying IGF-1 receptor binding, cell growth, and localized biological activity. This research-grade lyophilized powder is synthesized under strict quality controls and provided with full analytical documentation. For Research Use Only. Not for human use.
Key Scientific Features
- High-purity IGF-1 DES (1-3) (≥98% by HPLC/MS, receptor-grade)
- Verified 67-amino-acid truncated sequence (starting from position 4 of native IGF-1), as described by gropep.com
- Lyophilized formulation for maximum long-term stability
- Full Certificate of Analysis (COA) with HPLC, MS, amino acid analysis, and bioactivity assay
- Manufactured in GMP-aligned, ISO-compliant facilities
- Suitable for IGF-1 receptor binding studies, IGFBP interaction research, and cell growth investigations
Research-Referenced Attributes (Based on scientific literature; not intended as therapeutic claims.)
- Reduced IGFBP binding relative to native IGF-1, as noted by nbsbio.co.uk
- Ultra-short half-life resulting in highly localized activity in research models
- Studied in the context of satellite cell activation and cell proliferation in vitro
- Minimal systemic exposure profile — relevant for localized receptor activity studies
- Investigated in research contexts including cell growth, IGF receptors, and IGF binding proteins per gropep.com
Why Researchers Choose IGF-1 DES
- Exact truncated sequence used in peer-reviewed IGF-1 receptor research
- Transparent analytical data (HPLC >98%, MS confirmation of 67-aa length)
- Trusted by cell biology, receptor pharmacology, and regenerative research laboratories
- Competitive research pricing with bulk options
For Research Use Only. Not for human or animal use. Not intended to diagnose, treat, cure, or prevent any condition.
