Sermorelin (Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂) is the bioactive N-terminal fragment of the 44-amino-acid natural GHRH. As documented in peer-reviewed literature, Sermorelin selectively binds pituitary GHRH receptors to stimulate physiological, pulsatile GH secretion while preserving natural feedback loops — unlike exogenous hGH, which suppresses endogenous production (pubmed.ncbi.nlm.nih.gov). Once FDA-approved (1997–2008) for pediatric GH deficiency diagnostics and treatment, it remains a widely referenced compound for research on the adult GH axis. This research-grade lyophilized powder is synthesized under strict quality controls and provided with full analytical documentation. For Research Use Only. Not for human use.
Key Scientific Specifications
- High-purity Sermorelin (≥ 98% by HPLC/MS, acetate salt form)
- Exact 29-amino-acid GRF 1-29 sequence (identical to human GHRH 1-29)
- Lyophilized formulation for maximum long-term stability
- Full Certificate of Analysis (COA) with HPLC, MS, and amino acid analysis
- Manufactured in GMP-aligned, ISO-compliant facilities
- Suitable for pulsatile GH release studies, diagnostic challenge assays, and neuroendocrine research
Research-Referenced Characteristics (Based on published scientific literature; not intended as therapeutic or health claims. For laboratory research use only.)
- Studied for its role in modulating physiological pulsatile GH secretion patterns in GH-deficient and aging research models
- Investigated for dose-dependent, feedback-regulated effects on IGF-1 levels in preclinical models
- Shown to preserve natural GH negative feedback mechanisms in research settings — contrasting with direct hGH administration
- Subject of preclinical and historical studies examining effects on slow-wave sleep architecture and metabolic parameters
- Investigated in research contexts involving skeletal and immune system endpoints
- Used in combination research protocols alongside GHRP peptides (e.g., Ipamorelin, GHRP-2/6) for studies of GH pulse amplification
- Applicable to research investigating pituitary reserve and age-related neuroendocrine axis function
Why Researchers Choose This Sermorelin Peptide
- Exact clinical-sequence match (GRF 1-29, amidated C-terminus)
- High purity and documented bioactivity for research applications
- Transparent analytical data (HPLC >98%, MS confirmation)
- Used in endocrinology, neuroendocrine, and diagnostic research laboratories
- Competitive research pricing with bulk options available
For Research Use Only. Not for human or animal use. Not intended to diagnose, treat, cure, or prevent any condition.
