PE-22-28 Peptide

Price range: $53.00 through $64.00

PE-22-28 is a research-grade synthetic peptide that selectively blocks TREK-1 potassium channels for preclinical studies on neuronal and mood regulation.

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PE-22-28 is a synthetic analog derived from the endogenous sortilin propeptide, spadin, used in preclinical research to selectively block the TREK-1 potassium channel. It regulates neuronal excitability, synaptic plasticity, and mood-related behaviors in laboratory models. The peptide is produced under GMP-compliant conditions and supplied as a lyophilized powder with full quality documentation including a Certificate of Analysis. It acts as a potent antagonist of TREK-1, enhancing neuronal depolarization and serotonergic neuron activity. Research indicates its role in modulating TREK-1 activity, promoting hippocampal neurogenesis and synaptogenesis, and influencing stress and mood regulation in preclinical studies. It is intended for research use only and not for human use.

Additional information

Weight	.125 lbs
Dimensions	9 × 7 × .5 in
Size: No selection	5mg, 10mg

Peptide Research

Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity (2017) – https://pmc.ncbi.nlm.nih.gov/articles/PMC5601071/
Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design (2010) – https://pubmed.ncbi.nlm.nih.gov/20405001/
In vitro and in vivo regulation of synaptogenesis by the novel antidepressant spadin (2015) – https://pubmed.ncbi.nlm.nih.gov/25694029/ (related to spadin mechanisms applicable to analogs)
Spadin as a new antidepressant: absence of TREK-1-related side effects (2012) – https://pubmed.ncbi.nlm.nih.gov/21807005/
The Involvement of Sortilin/NTSR3 in Depression as the Progenitor of Spadin (2018) – https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.01541/full
Role of TREK-1 in Health and Disease, Focus on the Central Nervous System (2019 review) – https://pmc.ncbi.nlm.nih.gov/articles/PMC6470294/

Keep lyophilized peptides sealed in their original vial, protected from light and humidity, and store at -4°F or colder for optimal long-term stability in research settings; short-term refrigeration at around 39°F suffices for immediate use within weeks, though freezer storage maximizes integrity across extended research timelines.